Gates Foundation grant opens door to PhaSER project acceleration
The Bill & Melinda Gates Foundation has granted Edinburgh’s PhaSER Biomedical a US$2.3 million grant for its three year programme accelerating...
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The Bill & Melinda Gates Foundation has granted Edinburgh’s PhaSER Biomedical a US$2.3 million grant for its three year programme accelerating...
Edinburgh’s PhaSER Biomedical has received a $2.3m grant from the Bill & Melinda Gates Foundation to continue its work in drug discovery and development.
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The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because of their electrophilic nature, resulting in nonspecific reactions with active cysteine residues in a variety of cellular proteins. We show that genetic and pharmacologic inhibition of the Nrf2 repressor Bach1 in a posttreatment regimen of experimental PD is neuroprotective by up-regulating Bach1-targeted pathways involving both Nrf2-dependent antioxidant respons...
For people who take regular medication, or more than one type, Dundee Professor Roland Wolf's research is vital - and may change the future.