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Association of pneumococcal carriage in infants with the risk of carriage among their contacts in Nha Trang, Vietnam: A nested cross-sectional survey

Author summary Why was this study done? There is little information in the current literature on pneumococcal transmission to infants. Since individuals in this age group are at major risk of pneumococcal disease and at potentially reduced protection in reduced dose pneumococcal vaccination schedules, we carried out a study to identify their close contacts and likely routes of transmission. What did the researchers do and find? We identified all 7,428 physical contacts of 1,583 infants in Nha Trang, a coastal city in Vietnam. We found that there was a high correlation between infant infection and their probability of contact with at least 1 pneumococcal carrier on the surveyed day. Preschool-age children contributed around half of the total direct pneumococcal exposure risk to infants in Nha Trang. Around 80% of the exposure risk came from contact with household members. What do these findings mean? Social contact surveys can help to identify possible transmission pathways. I ....

United Kingdom , Nha Trang , Khá Hòm , Republic Of , Khanh Hoa , An Giang , Han I , Minh Xuan Bui , Kim Mulholland , Mirjamee Kretzschmar , Jason Hinds , Taqman Geneexpression Mastermix , Royal Society Grant , London School Of Hygiene Tropical Medicine , Pasteur Institute In Nha Trang , Merck Investigator Studies Program , Pasteur Institute Of Nha Trang , Khanh Hoa Health , World Health Organization , Khanh Hoa Health Service , Melinda Gates Foundation Grant , Career Development Fellowship , Murdoch Children Research Institute , National Institute Of Hygiene , Victorian Government Operational Infrastructure Support Program , Universitair Medisch Centrum Utrecht ,

How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology

Cross-protection from seasonal epidemics of human coronaviruses (HCoVs) has been hypothesized to contribute to the relative sparing of children during the early phase of the pandemic. Testing this relies on understanding the prepandemic age distribution of recent HCoV infections, but little is known about their dynamics. Using England and Wales as a case study, we use a transmission model to estimate the duration of immunity to seasonal coronaviruses, and show how cross-protection could have affected the age distribution of susceptibility during the first wave, and could alter SARS-CoV-2 transmission patterns over the coming decade. ....

United Kingdom , United States , City Of , Jamesd Munday , Rosannac Barnard , Katherinee Atkins , Fabienne Krauer , Rachel Lowe , Yalda Jafari , Akira Endo , Mark Jit , Damienc Tully , Gwenanm Knight , Kiesha Prem , Matthew Quaife , Annam Foss , Thibaut Jombart , Adamj Kucharski , C Julian Villabona , David Hodgson , Amy Gimma , Simonr Procter , Kevin Van Zandvoort , Fiona Yueqian Sun , Mihaly Koltai , Samuel Clifford ,