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Early Trial Finds Ruxolitinib Cream Safe, Effective Among Children With AD

In this phase 1 trial, researchers sought to investigate whether ruxolitinib cream is safe and tolerable in children aged 2 to 17 with atopic dermatitis (AD). ....

Global Assessment , Young Children , Atopic Dermatitis ,

Potential Combination Therapy Approaches with Ruxolitinib in Myelofibrosis

A review of recent trial data evaluating combination therapy approaches with ruxolitinib in myelofibrosis, including the rationale and potential clinical benefits associated with the use of these emerging strategies. ....

Myeloproliferative Neoplasms , Combination Therapy Approaches , Novel Combination Therapy , Jak2 Inhibitor , Pegylated Interferon Alpha , Bcl Xl , Bcl 2 , Transform 1 Trial , Transform 2 Trial ,

Selinexor/Ruxolitinib Combo Elicits Sustained Spleen Responses, Improves Symptoms in Myelofibrosis

The combination of selinexor at 60 mg and ruxolitinib induced rapid and durable spleen responses and improved symptoms at weeks 12 and 24 in patients with treatment-naïve myelofibrosis, according to updated data from the phase 1 XPORT-MF-034 trial. ....

Reshma Rangwala , Karyopharm Therapeutics Inc , Myelofibrosis Symptom Assessment Form , Myeloproliferative Neoplasms , Spleen Responses , Treatment Naïve Myelofibrosis , Aacr Annual Meeting , Phase 1 Xport Mf 034 Trial ,

Treatment Landscape in Atopic Dermatitis

Matthew Zirwas, MD, highlights therapies that are available for the treatment of atopic dermatitis, including corticosteroids, calcineurin inhibitors and JAK inhibitors. ....

Matthew Zirwas , Linda Stein Gold , Atopic Dermatitis , Topical Corticosteroids , Topical Calcineurin Inhibitors , Pde 4 Inhibitor , Jak Inhibitor ,

Incyte Announces European Commission Approval of Opzelura (ruxolitinib) Cream for the Treatment of Non-Segmental Vitiligo with Facial Involvement in Adults and Adolescents

Opzelura (ruxolitinib) Cream is the first approved treatment in the European Union (EU) to address repigmentation in non-segmental vitiligo Phase 3 data supporting the approval show treatment ....

United Kingdom , United States , Jean Marie Meurant , Catalina Loveman , Christine Chiou , Department Of Dermatology , European Commission , Journal Of The European Academy Dermatology , European Union , European Union Member States , Vitiligo International Patient Organizations Committee , Exchange Commission , Maruho Co Ltd , European Medicines Agency , Medicinal Products , Human Use , Union Member States , Chief Executive Officer , Vitiligo Area Scoring Index , New England Journal , Incyte Dermatology , Looking Statements , Product Characteristics , Dual Population Based , European Academy , Vitiligo Among Adults ,