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Major pathologic response to neoadjuvant pembrolizumab in advanced melanoma trial exceeds 50%

Major pathologic response to neoadjuvant pembrolizumab in advanced melanoma trial exceeds 50%
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United States , Sapnap Patel , Phyllis Gyorkey , Victorg Prieto , European Society Of Medical Oncology , University Of Texas Md Anderson Cancer Center , European Society , Medical Oncology , New England Journal , Phyllis Gyorkey Chair ,

Major pathologic response to neoadjuvant pemb

<p style="text-align:start">In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.&nbsp;These and other results of the analyses are presented as a proffered paper (Abstract LBA48) at the European Society of Medical Oncology (ESMO) Congress 2023 in Madrid, Spain, on Monday, October 23, by Sapna P. Patel, MD, chair of the SWOG melanoma committee and associate professor of melanoma medical oncology at the University of Texas MD Anderson Cancer Center.</p>
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United States , Vernonk Sondak , Michaelc Lowe , Aparna Hegde , Johnm Kirkwood , Kaiser Permanente , Thach Giao Truong , Elizabethi Buchbinder , Larissa Korde , G Paul Wright , Phyllis Gyorkey , Antoni Ribas , Victorg Prieto , Sapnap Patel , Megan Othus , Kari Kendra , Elad Sharon , John Hyngstrom , Sunandana Chandra , Craig Devoe , Data Management Center , Moffitt Cancer Center , University Of Utah Huntsman Cancer Institute , National Institutes Of Health , National Clinical Trials Network , Dana Farber Cancer Institute Harvard Center ,

Many melanoma patients could avoid the risk for toxicity from combination therapies, study suggests

Data from a national clinical trial shows that a striking 89% of patients with desmoplastic melanoma responded to immunotherapy (pembrolizumab) alone, suggesting that many patients could avoid the risk for toxicity from combination therapies and achieve cancer control with this approach to treatment. ....

United States , David Wada , Emily Henderson , Alexandra Ikeguchi , Garyc Doolittle , Elad Sharon , Nikhili Khushalani , Sapnap Patel , Kari Kendra , Katiem Campbell , Antoni Ribas , Joseph Markowitz , Zeynep Eroglu , Arthurg James , Josea Plaza , Toni Roberts , Shay Bellasea , Andres Brohl , Samer Kasbari , Jeffrey Sosman , George Negrea , John Hyngstrom , Michaelc Wu , Ohio State University College Of Medicine , Checkmate Pharmaceuticals , Richardj Solove Research Institute ,