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New research lays foundation for targeted therapies to inhibit NF-κB activation

A new paper by Dana-Farber Cancer Institute scientists lays the foundation for targeted therapies to inhibit activation of nuclear factor kappa B (NF-κB), a transcription factor that plays a role in various autoimmune and inflammatory diseases and cancers.

SwitzerlandSwissJamie pfaffWilliam kaelin jrNitin shiroleMary jane raoBarbara cohenBenjamin lampsonNational institutes of healthSwiss national science foundationHope funds for cancer researchHoward hughes medical instituteSarnoff cardiovascular research foundationDana farber cancer instituteFarber cancerFarber cancer institute

Research Reveals Drug Target for Disease-Linked NF-κB Activation

Research Reveals Drug Target for Disease-Linked NF-κB Activation
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SwitzerlandSwissBarbara cohenJamie pfaffNitin shiroleBenjamin lampsonMary jane raoWilliam kaelin jrHope funds for cancer researchDana farber cancer instituteSarnoff cardiovascular research foundationSwiss national science foundationHoward hughes medical instituteNational institutes of healthStudy titleFarber cancer institute

Pay-for-Performance May Worsen Existing Disparities, Study Shows

Pay-for-Performance May Worsen Existing Disparities, Study Shows
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United statesBostonMassachusettsHarvard universityAmericansPrihatha narasimmarajJiaman xuAshleyn kyalwaziHarvard medical schoolOutcomes researchNational heartMarcel zimetbaum fellowship in health outcomesCenters for medicare medicaid servicesHealth affairsBeth israel deaconess medical centerSusanf smith center

Dynamic Response to Oxygen Levels Unveiled

Dynamic Response to Oxygen Levels Unveiled
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CaliforniaUnited statesStanford universityMission baySan franciscoAmericanDanielle swaneyMichael matthayDave wentzAlan baikAugustinus haribowoAndrea fossatiErica stevensonSina ghaemmaghamiNabora reyesChan zuckerberg biohub

Scientists uncover cellular cause of heart defects in babies born to women with diabetes

When women with diabetes become pregnant, they face not only the typical challenges of pregnancy and impending parenthood, but also a scary statistic: they're five times more likely to have a baby with a congenital heart defect.

JapanUnited statesAmericanLyandysha zholudevaIrina sattuiArun padmanabhanBenjamin van soldtAngelo peloneroFeiya liMichael alexanianTomohiro nishinoYu huangNandhini sadagopanFrances kobackCasey giffordVan bemmel