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Radiation with immunotherapy increases lung cancer survival

Phase I study analysis determined immunotherapy with radiation is more effective than radiotherapy alone for non-small cell lung cancer. ....

Sean Pitroda , Nature Cancer , Assistant Professor , Cellular Oncology ,

Simultaneous radiation and immunotherapy can benefit mNSCLC patients with high tumor aneuploidy

In many cancer types, cancer cells try to survive by escaping attack from the immune system. These cancer cells hijack mechanisms called immune checkpoints to trick the immune system into thinking they are healthy cells. ....

Sean Pitroda , Emily Henderson , Lab Diagnostics Automation , University Of Chicago Pritzker School Medicine , Lab Diagnostics Automation Industry , Nature Cancer , Assistant Professor , Cellular Oncology , Automation Industry Focus , Chicago Pritzker School , Nature Genetics , Lung Cancer , Cancer Treatment , Immune System , Radiation Therapy ,

Chicago Research Awardees FY23

With lung diseases like COVID-19 and lung cancer, vaping and smoke from increased wildfires, lung health research has never been more important. Today, the American Lung Association in Greater Chicago announced that two researchers in the Windy City are being bestowed the Lung Cancer Discovery Award to help advance treatment responses to this devasting disease. ....

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University of Chicago study uncovers inhibitory role of 'Ter cells' in cancer therapies

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Targeted radiation is often used to study and treat diverse cancer types. A multidisciplinary research team based at the University of Chicago Medicine has recently focused on a type of cell that releases a protein that enhances resistance to cancer therapies and promotes tumor progression.
The study focused on Ter cells, which are extra medullary erythroid precursers that secrete the neuropeptide artemin. In the study, published February 24, 2020, in
Science Translational Medicine, the researchers showed that local tumor radiotherapy, systemic immunotherapy or the combination of both treatments were able to deplete Ter cells in the spleen, reduce artemin production and limit tumor progression both in the locally irradiated tumors as well as outside the radiation fields. ....

University Of Chicago , United States , Hyde Park , Orland Park , Fox Chase Cancer Center , Bernard Mitchell Hospital , Sean Pitroda , Yanbin Fu , Wenxin Zheng , Yang Xin Fu , Enyu Rao , Xinshuang Yu , Jason Bugno , Seanz Luo , Liangliang Wang , Xuezhi Cao , Xiaona Huang , Wenjun Wu , Jessica Jutzy , Ralph Weichselbaum , Ainhoa Arina , Anner Mccall , Steven Chmura , Zhida Liu , Xuzhou Medical University , Xian Jiaotong University ,