Researchers identify cellular serpins as host factors that restrict SARS-CoV-2 infection
Researchers investigated differences in susceptibility between individuals and may have discovered a new opportunity for treatment.
Source: news-medical.net
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Simulating molecular dynamics of SARS-CoV-2 spike variants in the locked conformation
Researchers retrieved the first-ever sequenced spike (S) protein structures of the original Wuhan-Hu 1 SARS-CoV-2 strain, the Alpha, Delta, Delta-plus variants, and Omicron sub-variants BA.1 and BA.2 and compared their structural and molecular level variations.
Source: news-medical.net
Elevated levels of PHGDH enzyme associated with Alzheimer's disease pathology
Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new evidence to support this claim.
Source: news-medical.net
Studying immunomodulatory effects of microbiota helps design prophylactic and therapeutic interventions against COVID-19
Researchers reviewed the potential clinically relevant mechanisms by which microbiota and microbiota-derived metabolites influence the host immune responses to SARS-CoV-2 infection.
Source: news-medical.net
SARS-CoV-2 Mpro inhibitors built on rattlesnake venom scaffold
A new study describes the development of new molecules with inhibitory activity against the SARS-CoV-2 viral main protease (Mpro) enzyme, based on rattlesnake venom.
Source: news-medical.net