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Study predicts which kids hospitalized with RSV likely to worsen | The Source | Washington University in St. Louis

Study predicts which kids hospitalized with RSV likely to worsen


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Children hospitalized with breathing problems due to a common viral lung infection are likely to get sicker and remain hospitalized if they have high levels of defective copies of the virus, according to a new study by researchers at Washington University School of Medicine in St. Louis.
The findings, published April 1 in
Nature Microbiology, could help doctors identify those patients at high risk of severe illness due to respiratory syncytial virus (RSV), the most common cause of pneumonia and bronchiolitis (inflammation of the small airways) in children under age 5.
Every child has been infected by RSV at least once before the age of 3, said senior author Carolina B. López, PhD, a professor of molecular microbiology and a BJC Investigator. Some infants and small children will just develop a cold, but others end up hospitalized. We don t really know what determines whether a child will get really sick or not. So when babies are admitted to the hospit ....

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Disruption of lung biological clock may explain flu risk in adults who survived premature birth


Disruption of lung biological clock may explain flu risk in adults who survived premature birth
Disruptions in the circadian rhythms in lung cells may explain why adults who survived premature birth are often more at risk of severe influenza infections, suggests a study in mice published today in
eLife.
Dramatic improvements in the care of infants born prematurely have allowed many more to survive into adulthood. Yet ex-preemies can face several long-term side effects of the life-saving care they received. The study suggests potential new approaches to treating lasting lung problems in those born prematurely.
Many premature infants are not able to breathe on their own and require oxygen to survive. But receiving too much oxygen may cause lasting damage to the lung that makes them more prone to severe flu infection later in life. In a previous study, senior author and neonatologist Shaon Sengupta, and her colleagues at the Children s Hospital of Philadelphia Resear ....

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