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Molecular detection platform provides new insights into gene medicine manufacturing

Molecular detection platform provides new insights into gene medicine manufacturing
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Huei Jeff Wang , Hai Quan Mao , Jeff Wang , Michaelj Mitchell , Nature Communications , Whiting School Of Engineering , Whiting School , Institute For Nanobiotechnology , Drug Administration , University Of Pennsylvania , Quan Mao , Mechanical Engineering , Biomedical Engineering , Materials Science , Skirkanich Assistant Professor ,

Molecular detection platform provides new insights into gene medicine manufacturing

Breakthrough medical technology like mRNA vaccines rely on tiny nanoparticles to deliver medicine to cells. A new device will help drug manufacturers and evaluators like the FDA more precisely measure genetic payloads to evaluate drug effectiveness. ....

Huei Jeff Wang , Hai Quan Mao , Bygina Wadaspublished , Michaelj Mitchell , Nature Communications , Whiting School Of Engineering , Whiting School , Institute For Nanobiotechnology , Drug Administration , University Of Pennsylvania , Quan Mao , Mechanical Engineering , Biomedical Engineering , Materials Science , Skirkanich Assistant Professor ,

iECURE Partners to Develop Next-Generation Liver-Targeted Lipid Nanoparticles with University of Pennsylvania

IECURE Partners to Develop Next-Generation Liver-Targeted Lipid Nanoparticles with University of Pennsylvania - read this article along with other careers information, tips and advice on BioSpace ....

Joseph Truitt , Roberts Langer , Michael Mitchell , Jamesm Wilson , University Of Pennsylvania Gene Therapy Program , National Institutes Of Health , Massachusetts Institute Of Technology , University Of Pennsylvania School Engineering , Upenn Gene Therapy Program , University Of Pennsylvania Penn , University Of Pennsylvania , Skirkanich Assistant Professor , Pennsylvania School , Gene Therapy Program , National Institutes , Postdoctoral Fellow , Massachusetts Institute , Gene Therapy , Ecure Partners To Develop Next Generation Liver Targeted Lipid Nanoparticles With University Of Pennsylvania ,

Penn engineers will develop on-demand, on-site mRNA manufacturing

Penn engineers will develop on-demand, on-site mRNA manufacturing
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Daeyeon Lee , Kathleen Stebe , Michael Mitchell , Melissa Pappas , Evanc Thompson , Department Of Mechanical Engineering , National Science Foundation , Frontiers In Research , Department Of Chemical , Distributed Ribonucleic Acid Manufacturing , Emerging Frontiers , Evanc Thompson Term Chair , Biomolecular Engineering , Elizabeth Goodwin Professor , Mechanical Engineering , Skirkanich Assistant Professor , Penn Engineering , மைக்கேல் மிட்செல் , மெலிசா பப்பச் , துறை ஆஃப் இயந்திர பொறியியல் , தேசிய அறிவியல் அடித்தளம் , எல்லைகள் இல் ஆராய்ச்சி , துறை ஆஃப் இரசாயன , வளர்ந்து வருகிறது எல்லைகள் , உயிர் மூலக்கூறு பொறியியல் , எலிசபெத் குட்வின் ப்ரொஃபெஸர் ,

New microfluidic device delivers mRNA nanoparticles a hundred times faster

With a ‘liquid assembly line,’ Penn researchers have produced mRNA-delivering-nanoparticles significantly faster than standard microfluidic technologies.
The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is the ability to package those sequences into the lipid nanoparticles that deliver them into cells.
The researchers’ new platform technology, called Very Large Scale Microfluidic Integration, allows tens of thousands of microfluidic units to be incorporated into a single three-dimensionally etched silicon-and-glass wafer. (Image: Penn Engineering Today) ....

Jamesm Wilson , Rakan El Mayta , Claude Warzecha , Lili Wang , Michael Mitchell , David Issadore , Sagar Yadavali , Mohamad Gabriel Alameh , Roseh Weiss Orphan Disease Center , Perelman School Of Medicine , Department Of Medicine , Nano Letters , Skirkanich Assistant Professor , Penn Engineering , Sarah Shepherd , Perelman School , Orphan Disease Center Director , Drew Weissman , லில்லி வாங் , மைக்கேல் மிட்செல் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , துறை ஆஃப் மருந்து , நானோ எழுத்துக்கள் , பென் பொறியியல் , சாரா மேய்ப்பன் , பெரல்மேன் பள்ளி ,