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With a ‘liquid assembly line,’ Penn researchers have produced mRNA-delivering-nanoparticles significantly faster than standard microfluidic technologies. The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is the ability to package those sequences into the lipid nanoparticles that deliver them into cells. The researchers’ new platform technology, called Very Large Scale Microfluidic Integration, allows tens of thousands of microfluidic units to be incorporated into a single three-dimensionally etched silicon-and-glass wafer. (Image: Penn Engineering Today)

Jamesm wilsonRakan el maytaClaude warzechaLili wangMichael mitchellDavid issadoreSagar yadavaliMohamad gabriel alamehRoseh weiss orphan disease centerPerelman school of medicineDepartment of medicineNano lettersSkirkanich assistant professorPenn engineeringSarah shepherdPerelman school