May 5, 2021
Therapeutic drug monitoring, half-dosing may not be ready for prime-time
Therapeutic drug monitoring (TDM) for patients with immune-mediated inflammatory diseases did not lead to better clinical remission rates, while routine dose reduction of anti-rheumatic drugs for patients with rheumatoid arthritis (RA) in remission offered modest benefits, according to two Norwegian trials.
In the NOR-DRUM Part A trial, clinical remission at week 30 was achieved in 50.5% of 198 patients with TDM versus 53% of 200 patients in the standard therapy group, for an adjusted difference of 1.5% (95% CI −8.2% to 11.1%,
P=0.78), reported Silje Watterdal Syversen, MD, PhD, of Diakonhjemmet Hospital in Oslo, and co-authors.
In the ARCTIC REWIND trial, disease flare occurred in 25% of 77 patients in the half-dose conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) group versus 6% in the stable-dose csDMARD group for a risk difference of 18% (95% CI 7%-29%), reported Si
Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.
Share:
International medical imaging IT and cybersecurity company Sectra
(STO: SECT B) has secured an enterprise imaging contract from the South-Eastern Norway Regional Health Authority. The contract comprises a radiology module and a region-wide multimedia solution (VNA) to store medical images and multimedia across all medical specialties. The platform will increase efficiency and collaboration across the region and beyond, translating into improved healthcare for its patients. We are pleased that we have the agreement in place. The regional solution is strongly needed and will improve the quality of patient care. Clinicians will have faster and easier access to patient information, thus can shorten lead times, comments Cathrine M. Lofthus, CEO, South-Eastern Norway Regional Health Authority (helse-sorost.no).