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Mixed Results with Refined Treatment Strategies for Rheumatic Diseases


May 5, 2021
Therapeutic drug monitoring, half-dosing may not be ready for prime-time
Therapeutic drug monitoring (TDM) for patients with immune-mediated inflammatory diseases did not lead to better clinical remission rates, while routine dose reduction of anti-rheumatic drugs for patients with rheumatoid arthritis (RA) in remission offered modest benefits, according to two Norwegian trials.
In the NOR-DRUM Part A trial, clinical remission at week 30 was achieved in 50.5% of 198 patients with TDM versus 53% of 200 patients in the standard therapy group, for an adjusted difference of 1.5% (95% CI −8.2% to 11.1%,
P=0.78), reported Silje Watterdal Syversen, MD, PhD, of Diakonhjemmet Hospital in Oslo, and co-authors.
In the ARCTIC REWIND trial, disease flare occurred in 25% of 77 patients in the half-dose conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) group versus 6% in the stable-dose csDMARD group for a risk difference of 18% (95% CI 7% ....

Silje Watterdal Syversen , Novartis Norge , Daiichi Sankyo , Eli Lilly , Infliximab Remicade , Siri Lillegraven , Shalmali Pal , Orion Pharma , Jeffreyr Curtis , Norwegian Regional Health Authorities , Boehringer Ingelheim , Thermo Fisher , University Of Alabama At Birmingham , South Eastern Norway Regional Health Authority , South Eastern Norway Regional Health Authorities , Research Council Of Norway , Diakonhjemmet Hospital , Contributing Writer , Norwegian Regional Health , Galderma Nordic , Bristol Myers Squibb , Merck Sharp , Research Council , South Eastern Norway Regional Health , Eisai Galapagos , தய்ச்சி சாங்கியோ ,

Consultant/Associate Professor till Lovisenberg Diakonale Sykehus, Oslo


Lovisenberg Diakonale Sykehus, Oslo
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Senior Consultant combined with Adjunct Professor/ Associate Professor (20 %) in medicine (Orthopaedic Surgery)
Lovisenberg Diaconal Sykehus AS (LDS) is a hospital for approximately 200,000 inhabitants in Oslo in the field of internal medicine and mental health care. Furthermore the hospital has extensive elective surgery activity with 9000 operations per year in the field of orthopaedic, ENT and General surgery. The hospital is owned by the diaconal foundations Diakonova and Diakonissehuset Lovisenberg, and has an operating agreement with South-Eastern Norway Regional Health Authority (HSØ RHF). The hospital is based on diaconal values with non-commercial purposes. You as an employee are expected to actively contribute to our core values of quality and charity. See www.lds.no  ....

Lars Vasli , Diakonissehuset Lovisenberg , Heidi Falch Ecklund , Anners Lerdal , Department For Quality , Research Department At Lovisenberg Diaconal Hospital , Institute Of Clinical Medicine , South Eastern Norway Regional Health Authority , University Of Oslo Ui , Orthopaedic Department , University Of Oslo , Lovisenberg Diaconal , Clinical Medicine , Associate Professor , Orthopaedic Surgery , Senior Consultant , Surgical Clinic , Research Department , Lovisenberg Diaconal Hospital , Adjunct Professorships , Surgical Clinic Lars Vasli , Director Anners Lerdal , Senior Advisor Human Resources , துறை க்கு தரம் , நிறுவனம் ஆஃப் மருத்துவ மருந்து , தெற்கு கிழக்கு நோர்வே பிராந்திய ஆரோக்கியம் அதிகாரம் ,

Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer