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Acquisition Complements Bruker’s Preclinical Imaging Portfolio with In-Vivo Optical Imaging

TUCSON, Ariz.--(BUSINESS WIRE)--Feb 6, 2024--

Rockville, United States, 2022-Apr-28 (Latestmarketreports) – Preclinical Brain Imaging Market has been evolving and changing over the course of past few decades and the market scope has changed a lot over the course of time and to better understand the market’s current landscape this report on Preclinical Brain Ima...

Preclinical imaging is a technique used to monitor animals for research purposes such as in new drug development. Preclinical imaging includes many different imaging modalities, in which only few are suitable for imaging small animals, and others can be used in large animals. Preclinical imaging is used by researche...

Brain metastases are among the most severe complications of systemic breast cancer, and overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer cells increases the incidence of brain metastases in patients. In this study, we engineered the human-derived, tumor cell tropic neural stem cells LM-NSC008 (LM008) to continuously secrete antibodies against HER2. These anti-HER2 antibodies impaired tumor cell proliferation by inhibiting the PI3K-Akt signaling pathway in HER2+ breast cancer cells in vitro. Importantly, our results demonstrate that the therapeutic combina...