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Alzheimer's Shown to Develop in Four Distinct Patterns


Alzheimer’s Shown to Develop in Four Distinct Patterns
Source: Ariel Skelley/Getty Images
May 3, 2021
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Nature Medicine that shows how the tau protein spreads in AD according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals.
“Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%,” write the investigators.

Sweden , Canada , Jacob-vogel , Oskar-hansson , Lund-university , Mcgill-university , Nature-medicine , Staging-inference , ஸ்வீடந் , கனடா , ஜாகோப்-வோகல் , லண்ட்-பல்கலைக்கழகம்

Alzheimer's has four distinct types; scientists find using machine learning [details]

An international team of scientists has found that Alzheimer's disease, a progressive neurodegenerative disease, has more than one distinct subtype, leveraging Machine Learning (ML)

Jacob-vogel , Allan-ajifo-flickr , Oskar-hansson , Representational-picture , Abnormal-tau-proteins , Brain-inflammation , Staging-inference , Alzheimers-disease , Alzheimers-disease-four-types , Four-types-of-alzheimers-disease , Subtypes-of-alzheimers-disease

Study shows how tau spreads to four distinct patterns leading to different Alzheimer's symptoms


Study shows how tau spreads to four distinct patterns leading to different Alzheimer's symptoms
Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in
Nature Medicine.
In contrast to how we have so far interpreted the spread of tau in the brain, these findings indicate that tau pathology in the brain varies according to at least four distinct patterns. This would suggest that Alzheimer's is an even more heterogeneous disease than previously thought. We now have reason to reevaluate the concept of typical Alzheimer's, and in the long run also the methods we use to assess the progression of the disease."

Sweden , United-states , Canada , Jacob-vogel , Oskar-hansson , Emily-henderson , Lund-university , Mcgill-university , Study-lead-author , Staging-inference , Alzheimer-39s-disease , Rain

Four Distinct Subtypes of Alzheimer's Disease


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Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in 
Nature Medicine.
"In contrast to how we have so far interpreted the spread of tau in the brain, these findings indicate that tau pathology in the brain varies according to at least four distinct patterns. This would suggest that Alzheimer's is an even more heterogeneous disease than previously thought. We now have reason to reevaluate the concept of typical Alzheimer's, and in the long run also the methods we use to assess the progression of the disease", says Jacob Vo-gel from McGill University, and the lead author of the study.

Sweden , United-states , Canada , Oskar-hansson , Lund-university , Mcgill-university , Jacob-vogel , Staging-inference , ஸ்வீடந் , ஒன்றுபட்டது-மாநிலங்களில் , கனடா , லண்ட்-பல்கலைக்கழகம்

Alzheimer's disease is composed of four distinct subtypes


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Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in
Nature Medicine.
"In contrast to how we have so far interpreted the spread of tau in the brain, these findings indicate that tau pathology in the brain varies according to at least four distinct patterns. This would suggest that Alzheimer's is an even more heterogeneous disease than previously thought. We now have reason to reevaluate the concept of typical Alzheimer's, and in the long run also the methods we use to assess the progression of the disease", says Jacob Vo-gel from McGill University, and the lead author of the study.

Sweden , United-states , Canada , Oskar-hansson , Lund-university , Mcgill-university , Jacob-vogel , Staging-inference , Medicine-health , Lzheimers-disease , ஸ்வீடந் , ஒன்றுபட்டது-மாநிலங்களில்