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Unlocking the Secrets of COVID-19: Why Some Populations Are Hit Harder Than Others

Throughout the COVID-19 pandemic, the range of clinical outcomes for individuals infected with SARS-CoV-2 varied widely, from showing no symptoms to succumbing to the disease. A research team from the Institut Pasteur, the CNRS, and the Collège de France collaborated with international scientists to ....

Central African Republic , Central Africans , Institut Pasteur , Maxime Rotival , Mary Oneill , Kathy Leung , Josepht Wu , Francesca Luca , Stefano Pietropaoli , Roberto Bruzzone , Vincent Bondet , Laurent Abel , Gaspard Kerner , Yann Aquino , Milena Hasan , Giovanna Barba Spaeth , Olivier Schwartz , Darragh Duffy , Jean Laurent Casanova , Cheuk Kwong Lee , Geert Leroux Roels , Zhi Li , Etienne Patin , Malik Peiris , Lluis Quintana Murci , Javier Mendoza Revilla ,

SARS-CoV-2: how the history of human populati

During the COVID-19 pandemic, the clinical spectrum observed among people infected with SARS-CoV-2 ranged from asymptomatic carriage to death. Researchers at the Institut Pasteur, the CNRS and the Collège de France, in collaboration with researchers around the world , have investigated the extent and drivers of differences in immune responses to SARS-CoV-2 across populations from Central Africa, Western Europe and East Asia. They show that latent cytomegalovirus infection and human genetic factors, driven by natural selection, contribute to population differences in immune response to SARS-CoV-2 and the severity of COVID-19. Understanding the factors underlying such population disparities could help to improve patient management in future epidemics. These results were published on August 9, 2023 in Nature. ....

Rockefeller University , New York , United States , University Hospital , University Of Hong Kong , Hong Kong General , Hong Kong , Central African Republic , France General , Central Africans , Roberto Bruzzone , Yann Aquino , Institut Pasteur , Laurent Abel , Sarah Helene Merkling , Li Ka Shing , Malik Peiris , Jean Laurent Casanova , Mickael Menager , Vincent Bondet , Mary Oneill , Zhi Li , Darragh Duffy , I Hong Kong , Giovanna Barba Spaeth , Francesca Luca ,