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Miniaturized Models Provide a Bigger Picture of ALS Source: wildpixel/Getty Images April 23, 2021 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Based on U.S. population studies, a little over 5,000 people in the United States are diagnosed with ALS each year. There are several research studies investigating possible risk factors that may be associated with ALS, however, more work is needed to conclusively determine what genetic and/or environmental factors contribute to developing ALS. Neuromuscular ju...

Recreating the Earliest Stages of Life Scientists generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos News provided by Share this article Share this article SAN FRANCISCO, April 23, 2021 /PRNewswire/ -- In their effort to understand the very earliest stages of life and how they can go wrong, scientists are confronted with ethical issues surrounding the use of human embryos. The use of animal embryos is also subject to restrictions rooted in ethical considerations. To overcome these limitations, scientists have been trying to ...

 E-Mail IMAGE: Scanning electron microscopy image of a human neuromuscular junction generated in microfluidic devices. Human induced pluripotent stem cell-derived motor neuron axons fan out and embed themselves into the human muscle... view more  Credit: Dr. Pieter Baatsen, LiMoNe, Research Group Molecular Neurobiology and Katarina Stoklund Dittlau, Laboratory of Neurobiology at VIB-KU Leuven Center for Brain and Disease Research Skeletal muscles enable voluntary movements and are controlled by a special type of neurons called motor neurons, which make direct contact with skeletal m...

New images of tangled, twisty blood vessels in the brains of elderly mice move us one step closer to unraveling the mysteries of the brain. Front-and-center are two major questions: What happens to the brain when it ages? And do male and female...

Credit: Monash University AUSTRALIAN - LED INTERNATIONAL RESEARCH TEAM GENERATES THE FIRST MODEL OF EARLY HUMAN EMBRYOS FROM SKIN CELLS In a discovery that will revolutionize research into the causes of early miscarriage, infertility and the study of early human development - an international team of scientists led by Monash University in Melbourne, Australia has generated a model of a human embryo from skin cells. The team, led by Professor Jose Polo, has successfully reprogrammed these fibroblasts or skin cells into a 3-dimensional cellular structure that is morphologically and molecularly...