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New malaria vaccine strain shows promise in preclinical trials

In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle Children's Research Institute and Sanaria Inc. describe the development of a whole malaria parasite vaccine strain that infects the liver, develops to the late liver stage, and then gets completely stuck and cannot burst out of the liver to cause symptomatic blood infection.

Germany , Gabon , Burkina-faso , Hardik-patel , B-kim-lee-sim , Peter-kremsner , Stephenl-hoffman , Debashree-goswami , Centre-de-recherches , University-of-washington , Seattle-children-research-institute , Ashley-vaughan-at-seattle-children-research-institute

Seattle Institute's New Malaria Vaccine Ready for Human Trials

Seattle Institute's New Malaria Vaccine Ready for Human Trials
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Germany , Gabon , Rockville , Maryland , United-states , Burkina-faso , Debashree-goswami , Stephenl-hoffman , Hardik-patel , B-kim-lee-sim , Peter-kremsner , Department-of-pediatrics

Letters: Ride-share companies need to be better regulated

Letters: Ride-share companies need to be better regulated
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Chicago , Illinois , United-states , New-york , Nicaragua , Washington , Highland-park , Homer-glen , Arlington-heights , Iraq , Dusable-high-school , Crestwood

Infectious malaria sporozoites produced without mosquitoes provide ground-breaking advances

Infectious malaria sporozoites produced without mosquitoes provide ground-breaking advances
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Switzerland , Barcelona , Comunidad-autonoma-de-cataluna , Spain , Swiss , Pedro-alonso , Stephenl-hoffman , Marcel-tanner , Global-malaria-program , University-of-barcelona , Swiss-academy-of-arts , Global-infectious-disease-research

Scientists report the in vitro production of infectious Plasmodium falciparum sporozoites

Scientists from Sanaria Inc., and collaborators at multiple institutions publish results in Nature reporting "In vitro production of infectious Plasmodium falciparum sporozoites."

Switzerland , Barcelona , Comunidad-autonoma-de-cataluna , Spain , Swiss , Pedro-alonso , Stephenl-hoffman , Marcel-tanner , Emily-henderson , Global-malaria-program , University-of-barcelona , Swiss-academy-of-arts

New genomic research reveals why testing malaria vaccines in clinic is as rigorous as natural exposure in field

New genomic research reveals why testing malaria vaccines in clinic is as rigorous as natural exposure in field
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Rockville , Maryland , United-states , Germany , University-of-maryland , Mali , Brazil , Joana , Bahia , Bamako , University-of-maryland-medical-center , Baltimore

New Genomic Research Shows Why Testing Malaria Vaccines in the Clinic is as Rigorous as Natural Exposure in the Field

New Genomic Research Shows Why Testing Malaria Vaccines in the Clinic is as Rigorous as Natural Exposure in the Field
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Rockville , Maryland , United-states , Germany , University-of-maryland , Mali , Brazil , Joana , Bahia , Bamako , University-of-maryland-medical-center , Baltimore

Md. Tech Council announces 2022 Industry Awards finalists

Md. Tech Council announces 2022 Industry Awards finalists
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Maryland , United-states , American , Steve-sidel , Matt-brown , Randy-altschuler , Douglas-falk , Rick-rudman , Frank-amato , Stephenl-hoffman , Sensors-inc , Global-alliant-inc

Novel malaria vaccine candidate gives strong, lasting protection


Malaria parasite. Photo: SENSISEEDSTwo United States (U.S.) Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedented high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites.
According to the study published, yesterday, in the journal Nature, by A. Mwakingwe-Omari et al and titled ‘Two chemo-attenuated PfSPZ malaria vaccines induce sterile hepatic immunity’, the vaccine combines live parasites with either of two widely used antimalarial drugs- an approach termed chemoprophylaxis vaccination.
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The researchers said a Phase 2 clinical trial of the vaccine is now underway in Mali, a malaria-endemic country. If the approach proves successful there, chemoprophylaxis vaccination, or CVac, potentially could help reverse the stalled decline of global malaria. Currently, there is no vaccine in widespread use for the mosquito-transmitted disease.

Rockville , Maryland , United-states , Bethesda , Mali , American , Patricke-duffy , Stephenl-hoffman , Clinical-centre-in-bethesda , United-states-national-institutes-of-health , National-institute-of-allergy

Sanaria researchers make progress in the development of highly protective malaria vaccine


Sanaria researchers make progress in the development of highly protective malaria vaccine
Researchers from Sanaria
® Inc. and the National Institutes of Health (NIH) are making progress in the development of highly protective malaria vaccines.
In an article published today in
Nature, Sanaria's PfSPZ-CVac (CQ) vaccine is reported as being safe and protecting 100% of six subjects against a variant malaria parasite three months after their last dose in the company's Phase 1 safety and efficacy trial. This is the first time complete protection against a variant malaria parasite has ever been achieved that long after vaccine administration.
The variant parasite used in the trial is a Brazilian malaria parasite genetically more variant from the African parasites in the vaccine than 700 malaria parasites from Africa. Protection was achieved at a dose that is 20% of the company's first-generation malaria vaccine dosage.

Brazil , Amsterdam , Noord-holland , Netherlands , Brazilian , Holm-keller , Sanaria-pf , Martin-grobusch , Stephenl-hoffman , Emily-henderson , Amsterdam-university-medical-centers , National-institutes-of-health