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Monte Rosa Therapeutics Announces Interim PK/PD and Clinical Data for MRT-2359 in Phase 1/2 Trial for MYC-Driven Solid Tumors

Monte Rosa Therapeutics Announces Interim PK/PD and Clinical Data for MRT-2359 in Phase 1/2 Trial for MYC-Driven Solid Tumors
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HIV Cure Program Releases Initial Clinical Trial Data

HIV Cure Program Releases Initial Clinical Trial Data
July 15, 2021 23:51 ET
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American Gene Technologies
American Gene Technologies
Rockville, Maryland, UNITED STATES
ROCKVILLE, Md., July 15, 2021 (GLOBE NEWSWIRE) American Gene Technologies (AGT) announced today that the Data and Safety Monitoring Board (DSMB) voted unanimously to continue AGT’s HIV cure program without modification, after safety analysis of the participant’s data revealed no adverse effects from the treatment. AGT’s Phase 1 trial of AGT103-T, a new cell and gene therapy for HIV disease, is designed to induce durable viral suppression by delivering therapeutic genes to the recipient s immune cells. The cells are collected by leukapheresis, modified outside the body, then re-infused. Once infused, the cells are expected to durably suppress the virus at undetectable levels without the need for antiretroviral treatment. ....

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AGT Announces Progress with HIV Cure Program, Phase 1 Clinical Trial

/PRNewswire/ American Gene Technologies (AGT), a clinical-stage biotechnology company, announced treatment of the first participant in its Phase I clinical. ....

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LGBT+ Investment Firm Gaingels Joins American Gene Technologies' Mission to Cure HIV, and Other Serious Human Diseases

LGBT+ Investment Firm Gaingels Joins American Gene Technologies Mission to Cure HIV, and Other Serious Human Diseases
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, an emerging gene and cell therapy company, announced today that Gaingels, a leading venture investment syndicate in service of the LGBT+ community and its allies, made an investment in AGT to support the Phase 1 clinical trial of an HIV cure. The Phase 1 human trial is investigating the safety of AGT103-T, a single dose, autologous cell therapy intended to cure the disease.
This investment places Gaingels alongside private investors who believe deeply in AGT s mission, rapid drug development platform, and gene and cell therapy programs for HIV, cancer, and PKU. ....

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Tessa Therapeutics Announces Successful Dosing of First Patient Cohort in Phase I Allogeneic Cell Therapy Trial

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BEDMINSTER, N.J. and SINGAPORE, Feb. 10, 2021 /PRNewswire/
Tessa Therapeutics Ltd. (Tessa), a clinical-stage cell therapy company developing next-generation cancer treatments for hematological malignancies and solid tumors, today announced the successful completion of dosing of the first patient cohort (n=3) in a Phase I dose escalation study, evaluating the safety and efficacy of Tessa s TT11X - Allogeneic CD30-CAR Epstein Barr Virus Specific T-cell (EBVST) therapy.
The Phase 1 study being conducted at Baylor College of Medicine aims to enroll up to 18 patients with CD30+ lymphoma across three dose levels. Study objectives are to evaluate safety and efficacy and establish dosing for the next phase. TT11X has been administered to three patients so far at Houston Methodist Hospital with a favorable safety profile. The therapy has been well tolerated with no evidence of GVHD or any severe adverse events associated with allogeneic therapies, ....

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