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Researchers discover new biological mechanism to regenerate and repair myelin

A study led by Dr. Hyun Kyoung Lee, associate professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, has discovered a new biological mechanism to regenerate and repair myelin, a protective sheath that insulates neuronal fibers and plays a vital role in ensuring rapid and accurate neurotransmission. ....

Chih Yen Wang , Juyeon Jo , Christine Madamba , Zhongyuan Zuo , Hugoj Bellen , Anthonyg Petrello , Hyun Kyoung Lee , Marka Wallace , Hyun Jung , Megan Craig , National Multiple Sclerosis Society , Baylor College Of Medicine , National Cheng Kung University , Proceedings Of The National Academy Science , Baylor College , Dan Duncan Neurological Research Institute , Texas Children , National Academy , National Cheng Kung , Kyoung In Kim , Sung Yun Jung , Eunice Kennedy Shriver National Institute , Child Health , Human Development , National Institutes , Cerebral Palsy ,

Silenced p16 gene can drive colorectal cancer progression

Colorectal cancer is the fourth most common and second deadliest cancer. How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models. ....

United States , Ya Cui , Xiaomin Chen , Lanjing Zhang , Jingyi Jessica Li , Jiejun Shi , Li Yang , Emilyb Lawrence , Sumimasa Arimura , Yumei Li , Lanlan Shen , Los Angeles , Nan Gao , Emily Henderson , Hyun Jung , Wei Li , Christy Lee , Journal Of Experimental Clinical Cancer Research , University Of California , Us Department Of Agriculture , Princeton Medical Center , Rutgers University , Baylor College Of Medicine , National Institutes Of Health , Baylor College , Clinical Cancer Research ,

Gene p16 Identified as Driver of Colorectal Cancer

Gene p16 Identified as Driver of Colorectal Cancer
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United States , Ya Cui , Lanjing Zhang , Emilyb Lawrence , Lanlan Shen , Li Yang , Christy Lee , Sumimasa Arimura , Los Angeles , Jiejun Shi , Yumei Li , Hyun Jung , Jingyi Jessica Li , Xiaomin Chen , Wei Li , Nan Gao , University Of California , Baylor College Of Medicine , National Institutes Of Health , Us Department Of Agriculture , Rutgers University , Journal Of Experimental Clinical Cancer Research , Princeton Medical Center , Baylor College , Clinical Cancer Research , Danl Duncan Comprehensive Cancer Center ,

Gene p16 drives colorectal cancer, potential therapy target

Colorectal cancer is the fourth most common and second deadliest cancer. How colorectal cancer develops is not well understood, but a team led by ....

United States , Li Yang , Nan Gao , Ya Cui , Lanjing Zhang , Emilyb Lawrence , Yumei Li , Jiejun Shi , Sumimasa Arimura , Jingyi Jessica Li , Christy Lee , Lanlan Shen , Los Angeles , Xiaomin Chen , Hyun Jung , Wei Li , Journal Of Experimental Clinical Cancer Research , Rutgers University , Princeton Medical Center , University Of California , Us Department Of Agriculture , Baylor College Of Medicine , National Institutes Of Health , Baylor College , Clinical Cancer Research , Danl Duncan Comprehensive Cancer Center ,

Changing the perspective on the 'Cinderella of the cytoskeleton'

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SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated or lost in several cancer types, most commonly a type of kidney cancer called clear-cell renal cell carcinoma, all eyes turned toward SETD2 function in the nucleus of the cell to explain these cancers.
In 2016, the lab of Dr. Cheryl Walker, director of the Center for Precision Environmental Health at Baylor College of Medicine, made the unexpected discovery that SETD2 not only remodels chromosomes in the nucleus, but also microtubules of the cytoskeleton outside the nucleus. The cytoskeleton is a dynamic network of interlinking protein thread-like structures, including filaments and microtubules that extend throughout the cell. It gives a cell its shape and internal organization and provides mechanical support that enables cells to carry out essential functions like ....

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