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KEY POINTS The first known diagnosis of SARS-CoV-2 infection in Canada was in a patient in hospital in Toronto on Jan. 25, 2020.[1][1] At the time, few anticipated the intensity and duration of the COVID-19 pandemic, which has presented health systems and governments globally with challenges not
Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time. Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvem...
Maximizing and evaluating the impact of test-trace-isolate programs: A modeling study Kyra H. Grantz , Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft Affiliation Department of Epidemiology, Johns Hopkins Bloomberg School of Public H...
Abstract Human eye color is highly heritable, but its genetic architecture is not yet fully understood. We report the results of the largest genome-wide association study for eye color to date, involving up to 192,986 European participants from 10 populations. We identify 124 independent associations arising from 61 discrete genomic regions, including 50 previously unidentified. We find evidence for genes involved in melanin pigmentation, but we also find associations with genes involved in iris morphology and structure. Further analyses in 1636 Asian participants from two populations suggest...