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Insomnia disorders as well as cardiometabolic disorders are highly prevalent in the psychiatric population compared to the general population. We aimed to investigate their association and evolution over time in a Swiss psychiatric cohort. Data for 2861 patients (8954 observations) were obtained from two prospective cohorts (PsyMetab and PsyClin) with metabolic parameters monitored routinely during psychotropic treatment. Insomnia disorders were based on the presence of ICD-10 “F51.0" diagnosis (non-organic insomnia), the prescription of sedatives before bedtime or the discharge let...

Substance abuse and addiction represent a significant public health problem that impacts multiple dimensions of society, including healthcare, the economy, and the workforce. In 2021, over 100,000 drug overdose deaths were reported in the US, with an alarming increase in fatalities related to opioids and psychostimulants. Understanding the fundamental gene regulatory mechanisms underlying addiction and related behaviors could facilitate more effective treatments. To explore how repeated drug exposure alters gene regulatory networks in the brain, we combined capped small (cs)RNA-seq, which accu...

During a cruise from October to November 2019 along the West Antarctic Peninsula between 64.32ºS and 68.37ºS, we assessed the diversity and composition of the active microbial eukaryotic community within three size fractions: micro- (>20µm), nano- (20-5µm), and pico-size fractions (5-0.2µm). The communities and the environmental parameters displayed latitudinal gradients, and we observed a strong similarity in the microbial eukaryotic communities as well as the environmental parameters, between the sub-surface and the deep chlorophyll maximum (DCM) depths. Chlorophy...

Introduction: Epilepsy affects about 50 million people worldwide, 80% of whom live in low- and middle-income countries. In Brazil, epidemiological studies are outdated and restricted to specific regions, mostly due to the country’s continental size. Objective: We aimed to present the first evidence-based study on epidemiological aspects of individuals with epilepsy, mapping the characteristics of this disease in a referral center in a region of Southeast Brazil. Methods: A retrospective study was carried out from January 2010 to March 2021. Patients were selected according to the Internation...

Plants are particularly vulnerable to physical disturbance in low productivity areas, due to the high energetic cost of replacing lost tissue. In the eastern United States, serpentine savannahs are fragmented ecosystems with high concentrations of rare endemic plant species, low concentrations of soil nutrients, and severe deer overpopulation. This study assessed the recovery of flowering plants in a serpentine savannah when deer were excluded. Plant count, flower count, vegetative area, and plant height of 10 serpentine plant species were compared inside and outside of deer exclusion structur...