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Shining a light on the hidden damage of mild

<p>We all know someone who&#39;s had a head injury that was &quot;only&quot; a concussion, but even mild traumatic brain injuries can cause lasting damage, and the vast majority are never diagnosed. A team led by Samir Mitragotri at the Wyss Institute, Harvard SEAS, and Boston Children&#39;s Hospital&nbsp;created a way to diagnose mild TBIs (mTBIs) even when MRI scans showed nothing, using the body&#39;s own immune cells called macrophages. They attached microparticle &quot;backpacks&quot; containing a common MRI contrast agent to the cells, which migrated to the brain and allowed them to see evidence of inflammation in pigs with a mock mTBI.</p>
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United States , Michael Dunne , Suyong Shaha , Samir Mitragotri , Lily Li Wen Wang , Rebekah Mannix , Rick Liao , Neha Kapate , Ninad Kumbhojkar , Bolu Ilelaboye , Andrew Lu , Tao Sun , John Clegg , Yongsheng Gao , Morgan Janes , Vineeth Chandran Suja , Solomina Darko , Masen Boucher , Kaitlyn Warren , Supriya Prakash , Camilo Jaimes , Directordonald Ingber , Wyss Institute , Us Department Of Defense Under Grant No , Method Of Research , Mitragotri Lab ,

Using the body's own cells to treat traumatic

<p>Traumatic brain injuries (TBIs) can cause lasting damage, but stopping the rampant brain inflammation they cause is difficult. A team at the Wyss, @SEAS and @MGH led by Samir Mitragotri has made a new treatment using macrophages - immune cells that migrate to the brain. By attaching microparticle &quot;backpacks&quot; that kept the macrophages in a healing state, they reduced the size of brain lesions by 56% in pigs with a mock TBI.</p>
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United States , Dania Villafuerte , Mikayla Flanz , Donald Ingber , Kolade Adebowale , Supriya Prakash , Bryan Golemb , Morgan James , Declan Mcguone , Beth Costine Bartell , Vineeth Chandran Suja , John Clegg , Ninad Kumbhojkar , Suyog Shaha , Rick Liao , Neha Kapate , Lily Li Wen Wang , Rohan Rajeev , Samir Mitragotri , Luke Sodemann , Michael Dunne , Yale School Of Medicine , Wyss Institute At Harvard University , Method Of Research , Us Department Of Defense Under Grant No , Harvard Medical School ,