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The 49ers quarterback was +2500 to win the MVP before the start of the season and is now the favorite at -190.
Eight underdogs pulled off straight-up wins in Week 14 causing a frenzy among NFL bettors and sportsbooks.
Big parlay payouts and some bad beats, along with San Francisco's big win in Philadelphia headline the betting action from Week 13.
Betting on underdogs was a fool's errand in Week 10, as favorites dominated for the third straight week.
It was a big day for the favorites, but Kansas City fans were left disgruntled over the lack of appearance of a certain pop star.