Live Breaking News & Updates on Swabi district

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Destitute in Defence in Pakistan – Sri Lanka Guardian

Destitute in Defence in Pakistan – Sri Lanka Guardian
slguardian.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from slguardian.org Daily Mail and Mail on Sunday newspapers.

Gwadar , Balochistan , Pakistan , Dera-ismail-khan , North-west-frontier , Swabi-district , Kech-district , Peshawar , Afghanistan , Islamabad , Quetta-district , Kurram-district

Local PTI leader gunned down in Swabi - Newspaper

JUI-Nazaryati candidate Qari Meharullah survives assassination attempt in Quetta.

Swabi , North-west-frontier , Pakistan , Quetta , Balochistan , Mehar , Sindh , Swabi-district , Sohail-yousafzai , Shah-khalid , Maulana-abdul-qadir , Qari-meharullah

Army, LEAs, nation cannot be coerced by terrorists: COAS

RAWALPINDI: Chief of Army Staff General Syed Asim Munir has emphasized that the Army, law enforcement agencies and the nation can never be coerced by the cowardly tactics of terrorists, who have a...

Sargodha-district , Punjab , Pakistan , Miranshah , Bannu , Afghanistan , Sahiwal-district , Rawalpindi , North-waziristan-district , Federally-administered-tribal-areas , Tirah , North-west-frontier

Tobacco Farmers Rejoice: A Long-Awaited Price Surge

Tobacco Farmers Rejoice: A Long-Awaited Price Surge
menafn.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from menafn.com Daily Mail and Mail on Sunday newspapers.

Iqbal-khan , Balochistan , Pakistan , Swabi , North-west-frontier , Dagai , Charsadda , Mardan , Philip-morris , Muhammad-ali-dagiwal , Khyber-tobacco-company , Pakistan-tobacco-company

Delayed justice in NMD's forced people towards old Jirga system – The Frontier Post

Delayed justice in NMD's forced people towards old Jirga system – The Frontier Post
thefrontierpost.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thefrontierpost.com Daily Mail and Mail on Sunday newspapers.

Peshawar , North-west-frontier , Pakistan , Gasht , Northern-areas , Halimzai , Federally-administered-tribal-areas , Gul-khan , Swabi-district , Ghalanai , Mohmand-district , Murad-khan

4 'militants' killed in twin KP operations - Pakistan

Two militants blew themselves up after law enforcement personnel encircled their hideout in Swabi.

Dera-ismail-khan , North-west-frontier , Pakistan , Kulachi , Balochistan , Swabi , Swabi-district , Najamul-hassan , Chota-lahor , Naseeb-khan , Terrorism-department , Swabi-district-police

Pakistan : 4 terrorists killed in twin operations

Uniindia: Islamabad, Jan 31(UNI) Pakistani armed forces killed four terrorists while another surrendered in two intelligence-based operations in Swabi and Dera Ismail Khan districts of Khyber Pakhtunkhwa on Monday.

Pakistan , Islamabad , Swabi , North-west-frontier , Dera-ismail-khan , Swabi-district , Pakistani , Najamul-hassan , Chota-lahor , Swabi-district-police , Khyber-pakhtunkhwa

Cureus | Non-syndromic Intellectual Disability: An Experimental In-Depth Exploration of Inheritance Pattern, Phenotypic Presentation, and Genomic Composition

Background

Intellectual disability (ID), also termed mental retardation (MR), is a neurodevelopmental disorder characterized by an intelligence quotient (IQ) of 70 or below and a deficit in at least two behaviors associated with adaptive functioning. The condition is further classified into syndromic intellectual disability (S-ID) and non-syndromic intellectual disability (NS-ID). This study highlights the genes associated with NS-ID.

Objectives

A genetic study was performed on two Pakistani families to know the inheritance patterns, clinical phenotypes, and molecular genetics of affected individuals with NS-ID.

Methodology

Samples were collected from two families: families A and B. All affected individuals in both families were diagnosed by a neurologist. Written informed consent was taken from the affected individuals and guardians before collecting the data and sample. Family A belongs to the Swabi District of Pakistan having four affected individuals, out of whom three were male and one was female. Family B also belongs to the Swabi District of Pakistan having two affected individuals, out of whom one was male and one was female. A total of 10 candidate genes were selected and were further screened by microarray analysis.

Results

In family A, this analysis identified a region of 9.6 Mb on chromosome 17q11.2-q12 between the single nucleotide polymorphisms (SNPs) rs953527 and rs2680398. The region was genotyped using microsatellite markers to confirm the haplotypes in all family members. Based on the phenotype-genotype relationship, 10 possible candidate genes were selected out of more than 140 genes in this critical region of 9.6 Mb. In family B, homozygosity mapping through microarray identified four homozygous areas of affected individuals: two (27,324,822-59,122,062 and 96,423,252123,656,241) on chromosome 8, one (14,785,224-19,722,760) on chromosome 9, and one (126173647-126215644) on chromosome 11.

Conclusion

An autosomal recessive pattern was found in the pedigrees of both families A and B. Phenotypically affected individuals showed IQ levels below 70. Three genes, CDK5R1, OMG, and EV12A, were found on chromosome 17q11.2-q12 region of affected individuals in family A with high expression in the frontal cortex of the brain, hippocampus, and spinal cord, respectively. Other regions on chromosomes 8, 9, and 11 as evident from the affected individuals in family B can also contribute to the non-syndromic autosomal recessive intellectual disability (NS-ARID). Further research is needed to find the association of these genes with intelligence and other neuropsychiatric conditions.

Swabi-district , North-west-frontier , Pakistan , Helsinki , Eteläuomen-läi , Finland , United-states , Pakistani , Affymetrix-genechip , Rutgers-university , Kohat-development-authority , Statistical-manual

Soldier martyred in shootout with terrorists in Khyber District

Soldier martyred in shootout with terrorists in Khyber District.

Rawalpindi , Punjab , Pakistan , Saleem-khan , Swabi-district , North-west-frontier , Liaquat-ali , Pakistan-army , Services-public-relations , A-pakistan-army , Dunya-news , Inter-services-public-relations

Pakistan Army soldier martyred, terrorist commander killed in Khyber IBO: ISPR

A Pakistan Army soldier was martyred during an intense exchange of fire with terrorists in the Khyber District of Khyber Pakhtunkhwa on November 7, the Inter-Services Public Relations said on...

Pakistan , Saleem-khan , Punjab , Swabi-district , North-west-frontier , Liaquat-ali , Pakistan-army , Services-public-relations , A-pakistan-army , Khyber-district , Khyber-pakhtunkhwa , Inter-services-public-relations