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Government entities owe PESCO Rs7b

PEDO, police among major defaulters

Haripur , Punjab , Pakistan , Lakki-marwat , North-west-frontier , Karak , Balochistan , Swabi , Peshawar , Bannu , Abbottabad , Lachi

Cureus | Non-syndromic Intellectual Disability: An Experimental In-Depth Exploration of Inheritance Pattern, Phenotypic Presentation, and Genomic Composition

Background

Intellectual disability (ID), also termed mental retardation (MR), is a neurodevelopmental disorder characterized by an intelligence quotient (IQ) of 70 or below and a deficit in at least two behaviors associated with adaptive functioning. The condition is further classified into syndromic intellectual disability (S-ID) and non-syndromic intellectual disability (NS-ID). This study highlights the genes associated with NS-ID.

Objectives

A genetic study was performed on two Pakistani families to know the inheritance patterns, clinical phenotypes, and molecular genetics of affected individuals with NS-ID.

Methodology

Samples were collected from two families: families A and B. All affected individuals in both families were diagnosed by a neurologist. Written informed consent was taken from the affected individuals and guardians before collecting the data and sample. Family A belongs to the Swabi District of Pakistan having four affected individuals, out of whom three were male and one was female. Family B also belongs to the Swabi District of Pakistan having two affected individuals, out of whom one was male and one was female. A total of 10 candidate genes were selected and were further screened by microarray analysis.

Results

In family A, this analysis identified a region of 9.6 Mb on chromosome 17q11.2-q12 between the single nucleotide polymorphisms (SNPs) rs953527 and rs2680398. The region was genotyped using microsatellite markers to confirm the haplotypes in all family members. Based on the phenotype-genotype relationship, 10 possible candidate genes were selected out of more than 140 genes in this critical region of 9.6 Mb. In family B, homozygosity mapping through microarray identified four homozygous areas of affected individuals: two (27,324,822-59,122,062 and 96,423,252123,656,241) on chromosome 8, one (14,785,224-19,722,760) on chromosome 9, and one (126173647-126215644) on chromosome 11.

Conclusion

An autosomal recessive pattern was found in the pedigrees of both families A and B. Phenotypically affected individuals showed IQ levels below 70. Three genes, CDK5R1, OMG, and EV12A, were found on chromosome 17q11.2-q12 region of affected individuals in family A with high expression in the frontal cortex of the brain, hippocampus, and spinal cord, respectively. Other regions on chromosomes 8, 9, and 11 as evident from the affected individuals in family B can also contribute to the non-syndromic autosomal recessive intellectual disability (NS-ARID). Further research is needed to find the association of these genes with intelligence and other neuropsychiatric conditions.

Swabi-district , North-west-frontier , Pakistan , Helsinki , Eteläuomen-läi , Finland , United-states , Pakistani , Affymetrix-genechip , Rutgers-university , Kohat-development-authority , Statistical-manual

Main accused gets death over Kohat medical student's murder - Newspaper

Peshawar court acquits two co-accused...

Peshawar , North-west-frontier , Pakistan , Dubai , Dubayy , United-arab-emirates , Pakistani , Mohammad-irfan , Mian-saqib-nisar , Shabbir-hussain-gigyani , Shah-zeb , Mian-abdul-fayyaz

Woman accused of killing girl child arrested in Kohat

Woman accused of killing girl child arrested in Kohat
Peshawar
April 8, 2021
KOHAT: The police on Wednesday claimed to have arrested a woman involved in the murder of a four-year-old girl in Khattak Colony a few days back.
Speaking at a press conference, District Police Officer Sohail Khalid said that Hareem Fatima, daughter of Naveed Iqbal and resident of Khattak Colony, had gone missing on March 24 last.
Soon after the incident, he said a team of expert police officials along with other departments, including Town Municipal Administration and civil intelligence officials, was constituted and launched a search operation for the recovery of the missing child.

Tayyab-hafeez-cheema , Sohail-khalid , Naveed-iqbal , Regional-police , Kohat-development-authority , District-police , Town-municipal-administration , Khattak-colony , District-police-officer-sohail-khalid , Hareem-fatima , First-information-report

Body of missing girl child recovered from sewerage in Kohat

Body of missing girl child recovered from sewerage in Kohat
thenews.com.pk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thenews.com.pk Daily Mail and Mail on Sunday newspapers.

Tayyab-hafeez-cheema , Farhad-hussain , Sohail-khalid , Naveed-iqbal , Regional-police , Kohat-development-authority , District-police , Town-municipal-administration , Khattak-colony , Harim-fatima , District-police-officer-sohail-khalid , First-information-report