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The research, published in PNAS May 8, shows a metabolite called succinate plays a role in enhancing cancer cell plasticity and identifies an enzyme called PLOD2 as a regulator of succinate during breast cancer progression.
Ermium Therapeutics, a discovery-stage biotechnology company developing innovative therapies for auto-immune diseases, particularly systemic lupus erythematosus and other interferonopathies, using immunomodulators
E-Mail Peroxisomes are essential, membrane-enclosed vesicles that occur in every cell. An arsenal of enzymes inside them breaks down harmful substances, thereby detoxifying the cells. A team of scientists led by Prof. Dr. Bettina Warscheid from the University of Freiburg, Prof. Dr. Ralf Erdmann from the Ruhr University Bochum and Prof. Dr. Christos Gatsogiannis from the University of Münster, formerly at the Max Planck Institute (MPI) of Molecular Physiology in Dortmund, has studied the molecular complex that carries the enzymes to where they are needed in the peroxisome. They have been ab...