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Alpha Agonists Treat ADHD in Preschoolers with Fewer Side Effects than Stimulants


May 11, 2021
Alpha-2 adrenergic agonists may effectively treat ADHD in preschoolers with fewer side effects than first-line stimulant medications, according to a new study published  in the
Journal of the American Medical Association that claims to be the first to compare the two classes of ADHD medication in preschool-aged children
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The health records of nearly 500 children (primarily males) revealed that 78% of children treated with stimulants showed an improvement in ADHD symptoms, while 66% of preschoolers who took an alpha agonist (like guanfacine) showed improved symptoms. However, participants taking the latter reported fewer side effects namely, lower rates of moodiness/irritability, appetite loss, and difficulty sleeping. Dr. Tanya Froehlich, professor and research director at Cincinnati Children’s Hospital Medical Center, explained: “For young children with ADHD who haven’t had enough improvement with behavioral therapy, both methylpheni ....

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