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Potential New Targets Identified in Advanced Non-Alcoholic Fatty Liver Disease

Using the latest technologies including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize ke ....

United States , New York , United Kingdom , City Of , Sammi Wang , Eliana Pickholz Li , Arthurm Fishberg , Martin Borch Jensen , Scottl Friedman , Division Of Liver Diseases , Uri Alon Weizmann Institute Of Science , Miri Adler Yale University School Of Medicine , Ruslan Medzhitov Yale University School Of Medicine , Li Chen Pharmanest Inc , National Institutes Of Health , Xiao Liu University Of California , Ross Dobie University Of Edinburgh , Tatiana Kisseleva University Of California , Kyliep Matchett University Of Edinburgh , Mathieu Petitjean Pharmanest Inc , Icahn School Of Medicine At Mount Sinai , Neilc Henderson University Of Edinburgh , Icahn School , Science Translational Medicine , Therapeutic Discovery , Liver Diseases ,

How Antibodies Help to Treat Liver Fibrosis?

How Antibodies Help to Treat Liver Fibrosis?
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Immunotoxins Targeted at Mesothelin to Treat Liver Disease

Immunotoxins Targeted at Mesothelin to Treat Liver Disease
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Ira Pastan , Tatiana Kisseleva , School Of Medicine , University Of California San Diego , National Cancer Institute , California San Diego , பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , தேசிய புற்றுநோய் நிறுவனம் , கலிஃபோர்னியா சான் டியாகோ ,

Selective, toxin-bearing antibodies could help treat liver fibrosis

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IMAGE: Normal liver tissues (left) do not produce mesothelin, while liver tissue from patients with primary sclerosing cholangitis do (right, darker staining). Mesothelin is a marker of liver fibrosis, and the.
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Credit: UC San Diego Health Sciences
Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.
So we thought.what if we take immunotoxins and try to get them to kill collagen-producing cells in the liver, said team lead Tatiana Kisseleva, MD, PhD, associate professor of surgery at UC San Diego School of Medicine. If these antibodies carrying toxic molecules can find and bind the cells, the cells will eat up the gift and die. ....

San Diego , United States , University Of California San Diego , Kojiro Taura , Takahiro Nishio , Jacopo Baglieri , Tapank Bera , Jamess Hagood , Yukinori Koyama , Tatiana Kisseleva , Keiko Iwaisako , Gen Yamamoto , Lauran Brenner , Ira Pastan , Davida Brenner , Nicholasf Larusso , Xiao Liu , Sarab Rosenthal , Doshisha University , National Cancer Institute , Shangai University Of Medicine , Kyoto University , National Institutes Of Health , Harvard Medical School , Proceedings Of The National Academy Sciences , University Of North Carolina At Chapel Hill ,

Selective immunotoxins may help treat liver fibrosis

Selective immunotoxins may help treat liver fibrosis
Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.
So we thought…what if we take immunotoxins and try to get them to kill collagen-producing cells in the liver. If these antibodies carrying toxic molecules can find and bind the cells, the cells will eat up the gift and die.
Tatiana Kisseleva, MD, PhD, Team Lead, Associate Professor of Surgery, UC San Diego School of Medicine ....

San Diego , United States , University Of California San Diego , Ira Pastan , Tatiana Kisseleva , Emily Henderson , National Cancer Institute , Proceedings Of The National Academy Sciences , National Institutes Of Health , Uc San Diego School Of Medicine , California San Diego School , Diego School , National Academy , National Institutes , சான் டியாகோ , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , எமிலி ஹென்டர்சன் , தேசிய புற்றுநோய் நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , அக் சான் டியாகோ பள்ளி ஆஃப் மருந்து , கலிஃபோர்னியா சான் டியாகோ பள்ளி , டியாகோ பள்ளி , தேசிய கலைக்கழகம் , தேசிய நிறுவனங்கள் ,