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Suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis

Objective To estimate the associations between gestational weight gain (GWG) during pregnancy and neonatal outcomes in low and middle income countries.

Design Individual participant data meta-analysis.

Setting Prospective pregnancy studies from 24 low and middle income countries.

Main outcome measures Nine neonatal outcomes related to timing (preterm birth) and anthropometry (weight, length, and head circumference) at birth, stillbirths, and neonatal death.

Analysis methods A systematic search was conducted in PubMed, Embase, and Web of Science which identified 53 prospective pregnancy studies published after the year 2000 with data on GWG, timing and anthropometry at birth, and neonatal mortality. GWG adequacy was defined as the ratio of the observed maternal weight gain over the recommended weight gain based on the Institute of Medicine body mass index specific guidelines, which are derived from data in high income settings, and the INTERGROWTH-21st GWG st ....

United Kingdom , Nandita Perumal , Dongqing Wang , Wafaiew Fawzi , Parul Christian , Gilberto Kac , Tahmeed Ahmed , Brittany Briggs , Vishak Subramoney , Wenju Liu , Stephenh Kennedy , Fondo Nestl , Kathryng Dewey , Molin Wang , Canadian Institutes Of Health Research , Family Larsson Rosenquist Foundation , National Academy Of Medicine , European Union Seventh Framework Programme , Maria Cecilia Souto Vidigal Foundation Brazil , National Institutes Of Health , Paulo State Research Foundation , Technological Development Cnpq , Institute Of Medicine , World Health Organization , Melinda Gates Foundation , National Council For Scientific ,