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New study traces back the progenitor genomes causing COVID-19 and geospatial spread


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IMAGE: The progenitor (proCoV2) virus and its initial descendants arose in China, based on the earliest mutations of proCoV2 and their locations, which were traced back to occur 6-8 weeks prior.
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Credit: Sudhir Kumar, Temple University
In the field of molecular epidemiology, the worldwide scientific community has been steadily sleuthing to solve the riddle of the early history of SARS-CoV-2. Despite recent efforts by the World Health Organization, no one to date has identified the first case of human transmission, or patient zero in the COVID-19 pandemic.
Finding the earliest possible case is needed to better understand how the virus may have jumped from its animal host first to infect humans as well as the history of how the SARS-CoV-2 viral genome has mutated over time and spread globally. ....

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Technique to automatically discover simulation configurations for behaviors hard to test


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IMAGE: The research team at National Institute of Informatics developed a technique to search automatically for simulation configurations that test various behaviors of automated driving systems. This research was conducted under.
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Credit: © National Institute of Informatics
The research team led by Fuyuki Ishikawa at the National Institute of Informatics (NII, Japan) developed a technique to search automatically for simulation configurations that test various behaviors of automated driving systems. This research was conducted under the ERATO-MMSD project ( 1) funded by the Japan Science and Technology Agency (JST, Japan). The proposed technique iterates trials on simulations using an optimization method called evolutionary computation so that it discovers simulation configurations that lead to specific features of driving behaviors such as high acceleration, deceleration, and steering operation. The outcome of this research was present ....

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Personalised medications possible with 3D printing


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Customised medicines could one day be manufactured to patients individual needs, with University of East Anglia (UEA) researchers investigating technology to 3D print pills.
The team, including Dr Andy Gleadall and Prof Richard Bibb at Loughborough University, identified a new additive manufacturing method to allow the 3D printing of medicine in highly porous structures, which can be used to regulate the rate of drug release from the medicine to the body when taken orally.
Dr Sheng Qi, a Reader in Pharmaceutics at UEA s School of Pharmacy, led the research. The project findings, Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing , are published today in the ....

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