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Compound derived from thunder god vine could improve outcomes for pancreatic cancer patients

Compound derived from thunder god vine could improve outcomes for pancreatic cancer patients
The results of a pre-clinical study led by researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest how a compound derived from the thunder god vine an herb used in China for centuries to treat joint pain, swelling and fever is able to kill cancer cells and potentially improve clinical outcomes for patients with pancreatic cancer.
The medicinal plant s key ingredient, triptolide, is the basis of a water-soluble prodrug called Minnelide, which appears to attack pancreatic cancer cells and the cocoon of stroma surrounding the tumor that shields it from the body s immune system. Investigators recently published the study results in the journal ....

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Compound derived from thunder god vine could help pancreatic cancer patients

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PHOENIX, Ariz. Dec. 14, 2020 The results of a pre-clinical study led by researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest how a compound derived from the thunder god vine an herb used in China for centuries to treat joint pain, swelling and fever is able to kill cancer cells and potentially improve clinical outcomes for patients with pancreatic cancer.
The medicinal plant s key ingredient, triptolide, is the basis of a water-soluble prodrug called Minnelide, which appears to attack pancreatic cancer cells and the cocoon of stroma surrounding the tumor that shields it from the body s immune system. Investigators recently published the study results in the journal ....

United States , Steve Yozwiak , Daniel Von Hoff , Haiyong Han , Salk Cancer Center , Translational Genomics Research Institute Tgen , Tgen Pancreatic Cancer Program , National Institutes Of Health , Damon Runyon Cancer Research Foundation , National Foundation For Cancer Research , Salk Institute For Biological , Baylor Scott White Research Institute , Samuel Waxman Cancer Research Foundation , Tgen Molecular Medicine Division , Lustgarten Foundation Pancreatic Cancer Dream Team , Howard Hughes Medical Institute , Translational Genomics Research Institute , Molecular Medicine Division , Pancreatic Cancer , Distinguished Professor , Von Hoff , Traditional Chinese , Baylor Scott , White Research Institute , Salk Institute , Biological Studies ,