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FOXNEWS Fox News at Night June 4, 2024 04:58:00

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Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells. ....

Emily Henderson , Division Of Breast , Shinshu University School Of Medicine , Department Of Surgery , Endocrine Surgery , Shinshu University School , Thyroid Cancer , Growth Factor , Kinase Inhibitor , Ignaling Pathway ,

Study: Walking 10,000 Steps Per Day Can Reduce Risk Of Cancer, Dementia - Walk 10,000 Steps Per Day To Reduce Risk Of Cancer, Dementia: Study

Study: Walking 10,000 Steps Per Day Can Reduce Risk Of Cancer, Dementia - Walk 10,000 Steps Per Day To Reduce Risk Of Cancer, Dementia: Study
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Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center. ....

United States , Vivek Subbiah , Emily Henderson , University Of Texas Md Anderson Cancer Center , Drug Administration , Eastern Cooperative Oncology Group , Lancet Oncology , Study Corresponding Author , Associate Professor , Investigational Cancer Therapeutics , Manderson Cancer ,

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center. ....

United States , Vivek Subbiah , Eli Lilly , Emily Henderson , University Of Texas Md Anderson Cancer Center , Drug Administration , Eastern Cooperative Oncology Group , Lancet Oncology , Investigational Cancer , Loxo Oncology ,