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Mapping the Types and Traits of Immune Cells

In this interview, News-Medical speaks to two researchers each discussing their respective studies that have contributed to the Human Cell Atlas; Dr. Chenqu Suo and Dr. Cecilia Domínguez Conde from the Wellcome Sanger Institute. ....

United Kingdom , Juan Gaertner Shutterstock , Danielle Ellis , Sarah Teichmann , Cecilia Dom , Sarah Teichamnn , Genomics Centre At Human Technopole , University Of Seville , Wellcome Sanger Institute , Postdoctoral Fellowwellcome Sanger Institute , University Of Cambridge , Human Cell Atlas Initiative , Group Leader , Genomics Centre Of The Human Technopole , Research Centre For Molecular Medicine Ce , Chenqu Suo , Condeclinical Phd Student , Human Cell Atlas , Wellcome Sanger , Research Centre , Molecular Medicine , Genomics Centre , Human Technopole , Wellcome Trust Funded , Medical Genomics , Covid 19 ,

"Cancer Progression Gene Expression Profiling Identifies the Urokinase " by Elahe Minaei, Simon A. Mueller et al.

Cutaneous squamous cell carcinoma (cSCC) of the head and neck region is the second most prevalent skin cancer, with metastases to regional lymph nodes occurring in 2%–5% of cases. To further our understanding of the molecular events characterizing cSCC invasion and metastasis, we conducted targeted cancer progression gene expression and pathway analysis in non-metastasizing (PRI-) and metastasizing primary (PRI+) cSCC tumors of the head and neck region, cognate lymph node metastases (MET), and matched sun-exposed skin (SES). The highest differentially expressed genes in metastatic (MET and PRI+) versus non-metastatic tumors (PRI-) and SES included PLAU, PLAUR, MMP1, MMP10, MMP13, ITGA5, VEGFA, and various inflammatory cytokine genes. Pathway enrichment analyses implicated these genes in cellular pathways and functions promoting matrix remodeling, cell survival and migration, and epithelial to mesenchymal transition, which were all significantly activated in metastatic compared to non ....

Cutaneous Squamous Cell Carcinoma Cssc , Xtracellular Matrix Ecm , Atrix Metalloproteinase Mmp , Tumor Stroma , Rokinase Plasminogen Activator Upa , Rokinase Plasminogen Activator Receptor Upar ,

Study unveils the novel driver of cardiomyocyte loss

Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells. Using explanted human hearts, they found regions in which heart muscle was actively degenerated and identified a new gene, ZBTB11, that drives heart muscle cell degradation. The results were published in Cardiovascular Research on 17 May 2022. ....

Eva Van Rooij , Alexander Van Oudenaarden , Emily Henderson , Pathology Department , Cardiovascular Research , Hubrecht Institute , Aryan Vink , Ene Expression , Heart Disease , Heart Transplantation ,

APOB-specific T cells may contribute to inflammation and further the progression of atherosclerosis

Preventing atherosclerosis, the underlying cause of heart disease, means scientists need to understand how immune cells drive inflammation in the arteries. ....

Emily Henderson , Nature Cardiovascular Research , Albert Einstein College Of Medicine , Jolla Institute For Immunology , Professor Klaus Ley , Klaus Ley , Albert Einstein College , Cardiovascular Disease , Heart Disease ,

VAHTS Universal V8 RNA-seq Library Prep Kit for IIIumina

For transcriptome library preparation and developed specifically for Illumina high-throughput sequencing platform ....

Library Prep Kit , Library Prep Kit For Illumina , Application Note , Vazyme Biotech , Scrna Seq , Library Prep Kits , High Throughput Sequencing ,