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In patients with severe hypertriglyceridemia who are at risk for acute pancreatitis, the drug brought about triglyceride reductions of more than 50% in the phase 2 SHASTA-2 study.
A drug targeting mRNA essential for APO C-III production provided a 50% reduction in triglycerides in BRIDGE-TIMI 73a, the largest ever observed in a controlled trial.
New analysis of the REDUCE-IT trial suggested benefit of icosapent ethyl doesn't vary by Lp(a) level and confirmed risk for Lp(a) with high triglycerides but not cholesterol.
Semaglutide improved MASLD in this population, and weight loss associated with its use resulted in no significant changes in physical function, according to two presentations at CROI.
In patients with well-controlled cholesterol after a percutaneous coronary intervention, a higher triglyceride glucose index was tied to higher incidence of adverse clinical outcomes.
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