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Lean or diabetic subtypes predict increased all-cause and disease-specific mortality in metabolic-associated fatty liver disease | BMC Medicine

Metabolic-associated fatty liver disease (MAFLD) encompasses diverse disease groups with potentially heterogeneous clinical outcomes. We investigated the risk of all-cause and disease-specific mortality in MAFLD subgroups. Using the Korean National Health Insurance Service database, participants were divided into four subgroups: no MAFLD, MAFLD-diabetes, MAFLD-overweight/obese, and MAFLD-lean. Hazard ratios (HRs) and 95% confidence interval (CI) values for all-cause and disease-specific mortality according to MAFLD subgroups were analyzed using Cox proportional hazards models. Among 9,935,314 participants, those with MAFLD-diabetes showed the highest risk of all-cause and disease-specific mortality. The HRs (95% CI) for all-cause mortality were 1.61 (1.59–1.63), 1.36 (1.34–1.38), and 1.19 (1.18–1.20) in the MAFLD-diabetes, MAFLD-lean, and MAFLD-overweight/obese groups, respectively. The magnitude of cardiovascular disease and cancer-related risk showed the same patter ....

Eteläuomen Läi , United States , International Classification Of Diseases , Institutional Review Board Of Soongsil University , Korean National Health Insurance System , Korean National Statistical Office , International Classification , Institutional Review Board , Soongsil University , Korean Standard Classification , Charlson Comorbidity Index , Renal Disease Study , Two Sidedp Values ,