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Medical center will lead data aggregation initiative to support future drug research, development

Jun 1, 2021 Associations seen with many CSF measures, but not beta-amyloid Aortic stiffening was associated with cerebrospinal fluid (CSF) markers of neurodegeneration and Alzheimer’s disease, a cross-sectional study found. “Among our oldest participants, age 74 years and older, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis,” wrote Angela Jefferson, PhD, of Vanderbilt University in Nashville, Tennessee, and co-authors in “Central arterial stiffening m...

 E-Mail IMAGE: This image shows the close relationship between phospholipase D3 and the pathological hallmarks of Alzheimer's disease in tissue from the temporal lobe of a human brain. Phospholipase D3, which is... view more  Credit: Matthew Schrag A rare and controversial mutation in the phospholipase D3 (PLD3) protein - previously linked to Alzheimer's disease - interferes with PLD3's vital recycling function inside neurons. Matthew Schrag of Vanderbilt University Medical Center and colleagues report these new findings in a paper published April 8th in PLOS Genetics. About 1 per...