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Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1. Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated2. Mitochondria are often essential for apoptosis, a cell fate distinct from cellular senescence. During apoptosis, widespread mitochondrial outer membrane permeabilization (MOMP) commits a cell to die3. Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP)...

Trial participants with Spastic Paraplegia 50 (SPG50) and Charcot-Marie-Tooth disease type 4J (CMT4J) could benefit from this joint effort to manufacture...

Vector Core is a user-friendly athlete monitoring solution that provides teams with limited resources the data and insights previously only accessible to advanced teams.Boston, MA, May 17, 2023 --... | May 17, 2023

Vector Core is a user-friendly athlete monitoring solution that provides teams with limited resources the data and insights previously only accessible to...

Researchers Jack Griffith and Taghreed Al-Turki from the UNC School of Medicine have discovered that telomeres, located at the ends of chromosomes, possess enough genetic information to produce two small proteins with potentially potent biological properties. Telomeres, previously believed to be