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Continuous Operations in Microbial Biomanufacturing

Larger volumes for microbial systems, compared with mammalian cell culture, affect every aspect of continuous processing. Scale plays a critical role, as process economy is mainly governed by equilibration of occupation time of all unit operations. If the bioreactor volume is large and the occupation time is long, but the downstream units can process the culture fluid rapidly, then downstream capacity utilization falls. ....

Christoph Herwig , Vienna Institute Of Technology , Analytical Technology , Vienna Institute , Process Analytical Technology ,