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Serotonin transporters increase when depression fades, study shows


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IMAGE: Jonas Svensson, postdoc researcher
Center for Psychiatry Research
Department of Clinical Neuroscience, Karolinska Institutet
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Credit: Lou Almskog
Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy. The results are published in the journal
Translational Psychiatry.
Our results suggest that changes to the serotonin system are part of the biology of depression and that this change is related to the episode rather than a static feature - a state rather than a trait, says the study s last author Johan Lundberg, researcher at the Department of Clinical Neuroscience, Karolinsk ....

Viktor Kaldo , Karolinska Institutet , Cecilia Svanborg , Martin Schain , Jonase Svensson , Christer Halldin , Pontus Plav , Johan Lundberg , Jonas Svensson , Department Of Clinical Neuroscience , Swedish Research Council , Swedish Society For Medical Research , Lundbeck Foundation , Swedish Mental Health Foundation , Clinical Neuroscience , Region Stockholm , Swedish Society , Medical Research , Translational Psychiatry , ஜோஹன் லண்ட்பெர்க் , ஜோனாஸ் ஸ்வெந்‌ஸந் , துறை ஆஃப் மருத்துவ நரம்பியல் , ஸ்விட்ச் ஆராய்ச்சி சபை , ஸ்விட்ச் சமூகம் க்கு மருத்துவ ஆராய்ச்சி , மருத்துவ நரம்பியல் , பகுதி ஸ்டாக்‌ஹோல்ம் ,