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"Double Life" of Key Immune Protein Reveals New Strategies for Treating Cancer

A new study uncovers how targeting a specific immune cell surface receptor, PD-1, can enhance the effectiveness of cancer treatments by limiting its activity. Additionally, these insights lend support to emerging treatment approaches for autoimmune diseases conditions where the immune system mistake ....

Elliot Philips , Jun Wang , Xiang Peng Kong , Ruimin Pan , Jia Liu , Ianm Ahearn , Yong Zhou , Elliota Philips , Audun Kvalvaag , Antonio Garcia Espa , Michaell Dustin , Alexander Leithner , Kadam Mor , Annas Tocheva , Hong Liang , Danr Littman , Christinac Luo , Zhihua Qin , Vilcek Institute Of Biomedical Sciences , Grossman School Of Medicine , Langone Health Perlmutter Cancer Center , Melanoma Research Alliance , Department Of Biochemistry , Bristol Myers Squibb , Colton Center , Langone Health ,

'Double life' of key immune protein reveals new strategies for treating cancer and autoimmune diseases

'Double life' of key immune protein reveals new strategies for treating cancer and autoimmune diseases
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Jun Wang , Elliot Philips , Xiang Peng Kong , Department Of Biochemistry , Grossman School Of Medicine , Bristol Myers Squibb , National Institutes Of Health , Perlmutter Cancer Center , University Of Oxford , Vilcek Institute Of Biomedical Sciences , Department Of Pathology , Colton Center , Langone Health Perlmutter Cancer Center , Research Council Of Norway , Langone Health , Melanoma Research Alliance , Kennedy Trust For Rheumatology Research , Science Immunology , Perlmutter Cancer , Vilcek Institute , Biomedical Sciences , Molecular Pharmacology , National Institutes , Kennedy Trust , Rheumatology Research , Research Council ,

Study reveals key mechanism of PD-1 function

Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows. ....

New York , United States , Comunidad Autonoma De Cataluna , University Of Texas , United Kingdom , Columbia University , Audun Kvalvaag , Ruimin Pan , Hong Liang , Xiang Peng Kong , Jun Wang , Ian Ahearn , Christina Luo , Zhihua Qin , Elliot Philips , Kadam Mor , Dan Littman , Jia Liu , Michael Dustin , Alexander Leithner , Alexander Morch , Yong Zhou , Anna Tocheva , Antonio Garcia Espana , Kennedy Trust For Rheumatology Research , Colton Center ,