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Powerful X-Rays Reveal Unique Differences in Neurons From People With Schizophrenia

25 FEBRUARY 2021
Capturing details of brain cells on a nanometre scale, researchers have uncovered evidence that the neurons of people with schizophrenia could have unique differences in thickness and curvature, and this might even account for some of their symptoms.

The finding comes from an analysis on just a small handful of donors, and is a long way from demonstrating how contrasting nerve cell structures might explain the neurological condition.
But as our understanding of these unusual characteristics grows, it could lead to better methods of treatment, helping give tens of millions around the world a better quality of life.
The study, led by researchers from Tokai University in Japan, made use of two different X-ray microscope technologies, one at the SPring-8 light source facility in Japan, the other at the US Department of Energy's Advanced Photon Source (APS).

Japan , Argonnex-ray-science-division , Tokai-university , Us-department-of-energy-advanced-photon-source , Advanced-photon-source , Vincent-de-andrade , X-ray-science , Neurons , X-ray , Brain , Amp-quot

Researchers use powerful X-rays to analyze brain tissues of schizophrenia patients

Researchers use powerful X-rays to analyze brain tissues of schizophrenia patients
Schizophrenia, a chronic, neurological brain disorder, affects millions of people around the world. It causes a fracture between a person's thoughts, feelings and behavior.
Symptoms include delusions, hallucinations, difficulty processing thoughts and an overall lack of motivation. Schizophrenia patients have a higher suicide rate and more health problems than the general population, and a lower life expectancy.
There is no cure for schizophrenia, but the key to treating it more effectively is to better understand how it arises. And that, according to Ryuta Mizutani, professor of applied biochemistry at Tokai University in Japan, means studying the structure of brain tissue. Specifically, it means comparing the brain tissues of schizophrenia patients with those of people in good mental health, to see the differences as clearly as possible.

Japan , Ryuta-mizutani , Emily-henderson , Argonnex-ray-science-division , Tokai-university , Argonne-national-laboratory , Us-department-of-energy , Office-of-science-user-facility , Applied-biochemistry , Advanced-photon-source , Science-user-facility , Super-photon-ring

Seeing schizophrenia: X-rays shed light on neural differences, point toward treatment

An international research team used the ultrabright X-rays of the Advanced Photon Source to examine neurons in the brains of schizophrenia patients. What they learned may help neurologists treat this harmful brain disorder.

Japan , United-states , America , Ryuta-mizutani , Uchicago-argonne , Argonnex-ray-science-division , Tokai-university , Us-department-of-energy , Office-of-science-user-facility , Argonne-national-laboratory-under-contract-no , Office-of-science , Argonne-national-laboratory