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Visualizing centriole genesis with microscopy and kinematic reconstruction techniques

Cells contain various specialized structures - such as the nucleus, mitochondria or peroxisomes - known as "organelles''.

Geneva , Genè , Switzerland , Paul-guichard , Virginie-hamel , Department-of-molecular , University-of-geneva , Cellular-biology , Brain , Ell , Icroscopy , Itochondria

The genesis of our cellular skeleton, image by image

The genesis of our cellular skeleton, image by image
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Virginie-hamel , Paul-guichard , Department-of-molecular , Cellular-biology ,

Scientists reconstruct assembly of the human centriole, image by image, for the first time

Scientists reconstruct assembly of the human centriole, image by image, for the first time
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Paul-guichard , Virginie-hamel , University-of-geneva , Department-of-molecular , Cellular-biology ,

Genesis Of Our Cellular Skeleton, Image By Image

Genesis Of Our Cellular Skeleton, Image By Image
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Paul-guichard , Virginie-hamel , Department-of-molecular , University-of-geneva , Cellular-biology ,

Christmas in a canoe comes to the Yukon Arts Centre

Main gallery show interprets a classic French fable

Northwest-territories , Canada , Israel , France , Great-lakes , Canada-general- , Ireland , Quebec , Canadians , French , Virginie-hamel , Mary-bradshaw

Researchers reveal native 3D structure of the ciliary base for the first time

Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling.

Geneva , Genè , Switzerland , Milan , Lombardia , Italy , Paul-guichard , Gaia-pigino , Ben-engel , Virginie-hamel , Emily-henderson , University-of-geneva

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.

Paul-guichard , Yvan-arsenijevic , Olivier-mercey , Virginie-hamel , Corinne-kostic , Emily-henderson , University-of-geneva , Department-of-molecular , University-of-lausanne , European-research-council , Pro-visu-foundation , Cellular-biology

Skeleton of malaria parasite reveals its secrets

Date Time
Skeleton of malaria parasite reveals its secrets
Research teams from UNIGE have discovered that the cytoskeleton of the malaria parasite comprises a vestigial form of an organelle called conoid, initially thought to be absent from this species and which could play a role in host invasion.
Plasmodium at the ookinete stage viewed by expansion microscopy. The image shows the cytoskeleton of the pathogen following the labelling of tubulin. The conoid is the ring visible at the upper tip of the cell. © UNIGE/HAMEL
Plasmodium is the parasite causing malaria, one of the deadliest parasitic diseases. The parasite requires two hosts -the Anopheles mosquito and the human- to complete its life cycle and goes through different forms at each stage of its life cycle. Transitioning from one form to the next involves a massive reorganisation of the cytoskeleton. Two teams from the University of Geneva (UNIGE) have shed new light on the cytoskeleton organisation in Plasmodium. Their research, published in PLOS Biology, details the organisation of the parasite’s skeleton at an unprecedented scale, adapting a recently developed technique called expansion microscopy. Cells are “inflated” before imaging, providing access to more structural details, at a nanometric scale. The study identifies traces of an organelle called “conoid”, which was thought to be lacking in this species despite its crucial role in host invasion of closely related parasites.

Virginie-hamel , Department-of-microbiology , University-of-geneva , Cell-biology , Vestigial-form , Mathieu-brochet , Molecular-medicine , University , Hamel , Geneva , Developmental , Pathogenesis