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Insights into how cancer cells adapt and rewire their metabolism to achieve growth and survive was accompanied by a call for tools to study this on a nearly single-cell level, according to a new paper in Nature Communications.

Share this article Share this article SAN DIEGO, Feb. 22, 2021 /PRNewswire/ -- BioAtla, Inc., a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics, today announced the publication by Proceedings of the National Academy of Sciences (PNAS) that describes the design and functionality of therapeutic antibody candidates utilizing BioAtla's proprietary CAB technology making them active only in the acidic tumor microenvironment while binding is reversibly inhibited in healthy tissue. This improved tumor targeting utiliz...

 E-Mail TAMPA, Fla. - Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process. This metabolic adaptation is referred to as the Warburg Effect, as it was first described by Otto Warburg almost a century ago. Ever since, the conditions that would evolutionarily select for cells to exhibit a Warburg Effect ...

Credits: Courtesy of the researchers *Terms of Use: Images for download on the MIT News office website are made available to non-commercial entities, press and the general public under a Creative Commons Attribution Non-Commercial No Derivatives license. You may not alter the images provided, other than to crop them to size. A credit line must be used when reproducing images; if one is not provided below, credit the images to "MIT." Caption: MIT biologists have found a possible explanation for the Warburg eff...