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Single-Cell Insights on Inaccessible Tumor Environments Expand Therapeutic Options


Single-Cell Insights on Inaccessible Tumor Environments Expand Therapeutic Options
Patient with melanoma leptomeningeal metastasis [Keiran Smalley/The Moffitt Cancer Center]
June 3, 2021
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While melanoma, a form of skin cancer that begins in the pigmented cells of the skin (melanocytes), is less common than other types of skin cancer, its seriousness lies in its ability to spread to other organs if not treated at an early stage. In nearly 75% patients, autopsy reveals the metastasis of melanoma to the central nervous system (CNS).
Of these, patients with the worst prognosis and rapid disease progression are those in whom melanoma spreads to the leptomeninges, the two innermost layers of the meninges that cover and protect the brain (leptomeningeal melanoma metastases, LMM). ....

Keiran Smalley , Department Of Cancer Physiology , Moffitt Cancer Center , Skin Cancers Center , Clinical Cancer Research , Inna Smalley , Assistant Member , Cancer Physiology , Moffitt Cancer , கேரான் ஸ்மல்லி , துறை ஆஃப் புற்றுநோய் உடலியல் , மாஃபிட் புற்றுநோய் மையம் , மருத்துவ புற்றுநோய் ஆராய்ச்சி , இன்ன ஸ்மல்லி , உதவியாளர் உறுப்பினர் , புற்றுநோய் உடலியல் , மாஃபிட் புற்றுநோய் ,

Spontaneous cell fusions amplify genetic diversity within tumors, Moffitt researchers say


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TAMPA, Fla. Evolution within groups of tumor cells follows the principles of natural selection, as evolution in pathogenic microbes. That is, the diversity of cellular characteristics within a group leads to differences in the ability of cells to survive and divide, which leads to selection for cells that bear characteristics that are most fit to the malignant environment. The ability to continuously create a diverse set of new cellular features enables cancers to develop the ability to grow in new tissue environments and to acquire resistance to anti-cancer drugs. The diversity of cell characteristics within groups of cancer cells can be created by a number of well-characterized mechanisms, including small-scale mutations, large-scale genomic changes involving losses, gains and reshuffling of large pieces of DNA, as well as by nongenetic mechanisms that create lasting changes in cellular features. At the same time, scientists generally believe that cancers lack a p ....

United States , Susang Komen , Andriy Marusyk , Revolution Program , National Cancer Institute , Cancer Physiology Department At Moffitt , Moffitt Cancer Center , Florida Bankhead Coley Cancer Research Program , American Cancer Society , Nature Ecology , Cancer Physiology Department , Cancer Physiology , Integrated Mathematical Oncology , Bankhead Coley Cancer Research Program , Cancer Biology , Medicine Health , ஒன்றுபட்டது மாநிலங்களில் , சுசாங் கோமேன் , பரிணாமம் ப்ரோக்ர்யாம் , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் உடலியல் துறை இல் மாஃபிட் , மாஃபிட் புற்றுநோய் மையம் , புளோரிடா வங்கித் தலை கோலி புற்றுநோய் ஆராய்ச்சி ப்ரோக்ர்யாம் , அமெரிக்கன் புற்றுநோய் சமூகம் , இயற்கை சூழலியல் , புற்றுநோய் உடலியல் துறை ,

Moffitt researchers identify how cancer cells adapt to survive harsh tumor microenvironments


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TAMPA, Fla. - Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process. This metabolic adaptation is referred to as the Warburg Effect, as it was first described by Otto Warburg almost a century ago. Ever since, the conditions that would evolutionarily select for cells to exhibit a Warburg Effect have been in debate, as it is much less efficient and produces toxic waste products. ....

Mehdi Damaghi , Otto Warburg , Robert Gillies , Cancer Physiology Department , National Cancer Institute , Proceedings Of The National Academy Sciences , Cancer Physiology Department At Moffitt Center , Moffitt Center , Warburg Effect , Moffitt Cancer , National Academy , Cancer Physiology , Medicine Health , ஒட்தோ வார்பர்க் , ராபர்ட் கில்லீஸ் , புற்றுநோய் உடலியல் துறை , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் உடலியல் துறை இல் மாஃபிட் மையம் , மாஃபிட் மையம் , வார்பர்க் விளைவு , மாஃபிட் புற்றுநோய் , தேசிய கலைக்கழகம் , புற்றுநோய் உடலியல் , மருந்து ஆரோக்கியம் ,