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Single-Cell Insights on Inaccessible Tumor Environments Expand Therapeutic Options


Single-Cell Insights on Inaccessible Tumor Environments Expand Therapeutic Options
Patient with melanoma leptomeningeal metastasis [Keiran Smalley/The Moffitt Cancer Center]
June 3, 2021
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While melanoma, a form of skin cancer that begins in the pigmented cells of the skin (melanocytes), is less common than other types of skin cancer, its seriousness lies in its ability to spread to other organs if not treated at an early stage. In nearly 75% patients, autopsy reveals the metastasis of melanoma to the central nervous system (CNS).
Of these, patients with the worst prognosis and rapid disease progression are those in whom melanoma spreads to the leptomeninges, the two innermost layers of the meninges that cover and protect the brain (leptomeningeal melanoma metastases, LMM). ....

Keiran Smalley , Department Of Cancer Physiology , Moffitt Cancer Center , Skin Cancers Center , Clinical Cancer Research , Inna Smalley , Assistant Member , Cancer Physiology , Moffitt Cancer , கேரான் ஸ்மல்லி , துறை ஆஃப் புற்றுநோய் உடலியல் , மாஃபிட் புற்றுநோய் மையம் , மருத்துவ புற்றுநோய் ஆராய்ச்சி , இன்ன ஸ்மல்லி , உதவியாளர் உறுப்பினர் , புற்றுநோய் உடலியல் , மாஃபிட் புற்றுநோய் ,

IMV's Lead Immunotherapy to be Investigated in Breast Cancer


Press release content from Business Wire. The AP news staff was not involved in its creation.
IMV’s Lead Immunotherapy to be Investigated in Breast Cancer
May 10, 2021 GMT
DARTMOUTH, Nova Scotia (BUSINESS WIRE) May 10, 2021
IMV Inc. (Nasdaq: IMV; TSX: IMV) (“IMV” or the “Company”), a clinical-stage biopharmaceutical company pioneering a novel class of cancer immunotherapies, today announced that its lead compound, maveropepimut-S (DPX-Survivac) will be investigated in patients with hormone receptor positive/HER2-negative (HR+/HER2-) breast cancer. HR+/HER2- tumors represent an unmet clinical need with relatively poor responses to neoadjuvant endocrine treatment 1. This investigator-initiated clinical study will be conducted at the Providence Cancer Institute in Portland, Oregon, and is expected to begin during summer 2021. ....

United States , Kristinah Young , Sashae Stanton , Merck Keytruda , Relationsmarc Jasmin , Cancer Immunoprevention Lab At Providence , National Cancer Institute , Joseph Health , Earlea Chiles Research Institute , Tumor Microenvironment Lab , Robertw Franz Cancer Center , European Medicines Agency , Providence Cancer Institute , Providence Cancer Institute In Portland , Frederic Ors , Chief Executive Officer , Assistant Member , Research Institute , Cancer Immunoprevention Lab , Fast Track , Orphan Drug , Cancer Institute , Cancer Center , Based Treatments , Clinically Relevant Subgroups , Negative Metastatic Breast Cancer ,

Study Shows All 3 FDA-Approved Vaccines Protect Against Current COVID Variants


According to the New York Blood Center analysis, the vaccines create enough antibodies to fight the disease
Published March 17, 2021 •
Updated on March 17, 2021 at 12:43 pm
NBC Universal, Inc.
What to Know
All three of the FDA-approved vaccines against COVID-19 show efficacy against the mutated strains of the virus, according to an analysis by the New York Blood Center (NYBC) published in 
Science Magazine.
NYBC found that the Pfizer, Johnson & Johnson, and Moderna vaccines create enough antibodies to fight the virus variants, according to the article “Vaccine efficacy probable against COVID-19 variants” by Dr. Christopher D. Hillyer and Dr. Larry Luchsinger.
However, according to the published analysis, the efficacy of vaccines need to be reexamined as new strains emerge. ....

New York , United States , Larry Luchsinger , Christopherd Hillyer , York Blood Center , New York Blood Center , Assistant Member , Research Institute , Corona Virus , Coronavirus Pandemic , Coronavirus Vaccine , Covid 19 , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , யார்க் இரத்தம் மையம் , புதியது யார்க் இரத்தம் மையம் , உதவியாளர் உறுப்பினர் , ஆராய்ச்சி நிறுவனம் , கொரோனா வைரஸ் ,

Newly discovered biochemical pathway can protect cells from ferroptosis


Newly discovered biochemical pathway can protect cells from ferroptosis
The hallmarks of cancer include rapid cell-reproduction and metabolic activity. But these processes also lead to increased cellular stress and oxidation, and the risk of cell death.
To circumvent these negative consequences of supercharged growth, cancer cells stimulate pathways to reduce oxidative stress and avoid cell death. In an article published in
Cell Metabolism, Moffitt Cancer Center researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis.
Ferroptosis is a specialized type of cell death that is caused by imbalances in oxidation within cells. Ferroptosis results in changes to molecules in the cell membrane called lipids and can be caused by cysteine starvation. ....

Gina Denicola , Emily Henderson , H Lee Moffitt Cancer Center Research Institute , Moffitt Cancer Center , Member Of The Cancer Physiology Department , Cell Metabolism , Study Lead Author , Assistant Member , Cancer Physiology Department , Amino Acid , Cell Death , Cell Membrane , Lung Cancer , Oxidative Stress , ஜினா டெனிகோலா , எமிலி ஹென்டர்சன் , ஏச் லீ மாஃபிட் புற்றுநோய் மையம் ஆராய்ச்சி நிறுவனம் , மாஃபிட் புற்றுநோய் மையம் , உறுப்பினர் ஆஃப் தி புற்றுநோய் உடலியல் துறை , செல் வளர்சிதை மாற்றம் , படிப்பு வழி நடத்து நூலாசிரியர் , உதவியாளர் உறுப்பினர் , புற்றுநோய் உடலியல் துறை , அமினோ அமிலம் , செல் இறப்பு , செல் சவ்வு ,