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A novel blood serum assay to diagnose neurode

Clusters of abnormally folded α-synuclein proteins, called seeds, trigger the formation of larger aggregates, leading to neurodegenerative disorders known as synucleinopathies. Researchers from Japan have developed a novel assay that can detect α-synuclein seeds in the blood. This new assay is highly sensitive, simple, quick, and can differentiate between synucleinopathies based on structural differences of the amplified seeds. This research was supported by the National Research Program for Neurological Disorders and Mental Health of the Japan Agency for Medical Research and Development (AMED). ....

Bunkyo Ku , Deborah Mcintyre , Daisuke Taniguchi , Michel Mittelbronn , Haruka Kimura , Taiji Tsunemi , Soichiro Kakuta , Nobutaka Hattori , Akihide Kondo , Ayami Okuzumi , Yoko Imamichi , Nobuyuki Nukina , Shinji Saiki , Shuko Nojiri , Taku Hatano , Takeshi Fukuhara , Manabu Funayama , Gen Matsumoto , Yasuo Uchiyama , Development Grants For Dementia , Welfare Sciences Research , Centre Hospitalier De Luxemburg , Technology Innovation Center , Ministry Of Education , Research On Policy Planning , Nagasaki University School Of Medicine ,

Muscle biopsy test for biomarker could lead to earlier diagnosis of ALS

Muscle biopsy test for biomarker could lead to earlier diagnosis of ALS
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Hideshi Kawakami , Tomomi Murao , Tomohito Sugiura , Hirofumi Maruyama , Yuishin Izumi , Takashi Kurashige , Kazuya Kuraoka , Hiroyuki Morino , Department Of Clinical Neuroscience , Tokushima University Graduate School , Department Of Neurology , Ministry Of Health , Hiroshima University , National Hospital Organization Kure Medical Center , Department Of Epidemiology , Health Sciences At Hiroshima University , Institute Of Biomedical Sciences , Japan Society For The Promotion Of Science , Health Sciences , Chugoku Cancer Center , School Of Biomedical , Taiju Life Social Welfare Foundation , National Hospital Kure Medical Center , Takeda Science Foundation , Department Of Diagnostic Pathology , Research On Policy Planning ,

Ultra-High Dose Drug Slows Functional Decline in Early ALS

An ultra-high dose of methylcobalamin slows functional decline and is safe in patients with early stage amyotrophic lateral sclerosis, results from a new phase 3 study suggest. ....

Ann Arbor , United States , Yuishin Izumi , Stephen Goutman , Department Of Neurology , Tokushima University Graduate School Of Biomedical Sciences , Ministry Of Health , Drug Administration , Research Committee , University Of Michigan , Research On Policy Planning , Welfare Sciences Research , Japan Agency For Medical Research , Building On Previous Research , Neuromuscular Program , Tokushima University Graduate School , Biomedical Sciences , Medscape Medical , Medscape Medical News , Japan Agency , Medical Research , Policy Planning , Intractable Diseases , Welfare Sciences Research Grants , Muscular Atrophy , Uscular Atrophies ,

Eisai: Fully Human Anti-TNFalpha Monoclonal Antibody HUMIRA Obtains Additional Approval

Eisai: Fully Human Anti-TNFalpha Monoclonal Antibody HUMIRA Obtains Additional Approval
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Pediatr Gastroenterol Nutr , Eisai Group , Abbvie Gk Eisai Co Ltd , Ajinomoto Group , Colitis Association , Ea Pharma Co Ltd , Eisai Co Ltd , Public Affairs , Welfare Sciences Research , Public Relations Department , High Dose Regimen , Ulcerative Colitis , Adult Patients , New Regimen , Monoclonal Antibody , Subcutaneous Injection , Fully Human , Allergan Aesthetics , Australian Crohn , Economic Costs ,