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New Bone Cell Type Identified, Could Point to Drug Targets for Osteoporosis and Other Skeletal Diseases


New Bone Cell Type Identified, Could Point to Drug Targets for Osteoporosis and Other Skeletal Diseases
February 26, 2021
Source: Photo by Mathew Schwartz on Unsplash
Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may yield novel therapeutic targets and strategies for osteoporosis and other skeletal diseases.
The cells, which the researchers have called osteomorphs, are found in the blood and bone marrow, and fuse together to form osteoclasts, which are specialized cells that break down bone tissue. The newly identified osteomorphs have a unique genomic profile that indicates potentially promising, and as yet unexplored targets for therapy. ....

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Descubren un nuevo tipo de célula ósea que podría revelar objetivos para el tratamiento de la osteoporosis

Descubren un nuevo tipo de célula ósea que podría revelar objetivos para el tratamiento de la osteoporosis
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New type of bone cell could reveal targets for osteoporosis treatment


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Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases.
The new cells, which the researchers term osteomorphs , are found in the blood and bone marrow, and fuse together to form osteoclasts, specialised cells that break down bone tissue. They have a unique genomic profile that reveals promising and as yet unexplored targets for therapy.
This discovery is a game-changer, which not only helps us understand bone biology but presents significant new in-roads for osteoporosis therapy, says co-senior author Professor Tri Phan, who heads the Intravital Microscopy and Gene Expression Lab at the Garvan Institute. Osteomorphs express several genes that seem to be linked to bone disease, which could lead scientists to entirely new ways to target osteoporosis. ....

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