The role of molecular interactions in cell differentiation and cancer invasion
This article outlines the role of molecular interactions in cell differentiation and cancer invasion.
Source: news-medical.net
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Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione
P2RY8 is a G protein–coupled receptor (GPCR) that is involved in restraining germinal center (GC) B cell migration and growth. It is unclear how the ligand of P2RY8, S -geranylgeranyl-l-glutathione (GGG), is involved in these processes. Using gain-of-function mouse models and genetically modified human T cells, Gallman et al. showed that expression of gamma-glutamyltransferase-5 (Ggt5) on stromal cells and ATP-binding cassette subfamily C member 1 (Abcc1) on hematopoietic cells was involved in catabolizing and transporting GGG, respectively, and restraining P2RY8+ cells within GCs. GGG and P...
Source: sciencemag.org