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Frontiers | Factors Associated With Severity of Delirium Complicating COVID-19 in Intensive Care Units

The clinical outcome of the disease provoked by the Sars-CoV-2 infection, COVID-19, is largely due to the development of interstitial pneumonia accompanied by an Acute Respiratory Distress Syndrome (ARDS), often requiring ventilatory support therapy in Intensive Care Units (ICUs). Current epidemiologic evidence is demonstrating that the COVID-19 prognosis is significantly influenced by its acute complications. Among these, delirium figures as one of the most frequent and severe, especially in the emergency setting, where it shows a significantly negative prognostic impact. In this regard, the aim of our study is to identify clinical severity factors of delirium complicating COVID-19 related-ARDS. We performed a comparative and correlation analysis using demographics, comorbidities, multisystemic and delirium severity scores and anti-delirium therapy in two cohorts of ARDS patients with delirium respectively due to COVID-19 (n=40) or other medical conditions (n=39). Our results indicate that delirium in COVID-19-related ARDS is more severe since its onset despite a relatively less severe systemic condition at the point of ICU admission and required higher dosages of antipsychotic and non-benzodiazepinic sedative therapy respect to non-COVID patients. Finally, the linear regression analysis demonstrates a direct correlation between the multisystemic severity score, and the haloperidol maximum dosage needed to treat the delirium within the COVID-19 group, taken as a surrogate of delirium severity. Overall, our results seem to indicate that pathogenetic factors specifically associated to severe COVID-19 are responsible for the high severity of delirium, paving the way for future research focused on the mechanisms of the cognitive alterations associated with COVID-19.

Italy , Milan , Lombardia , United-states , Zierau , Sachsen-anhalt , Germany , Washington , China , Wuhan , Hubei , Berlin

Hamburg & Schleswig-Holstein: Corona lässt Kieler Finanznot wachsen

Aktuelle Nachrichten aus Hamburg und Schleswig-Holstein

Schleswig , Schleswig-holstein , Germany , Zierau , Sachsen-anhalt , Kiel-financial-need , Household-management , Schleswig-holstein-state-capital-keel , Lord-mayor-fighter , Treasurer-zierau-thursday , Board-meeting

Corona lässt Kieler Finanznot wachsen

Corona lässt Kieler Finanznot wachsen
abendblatt.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from abendblatt.de Daily Mail and Mail on Sunday newspapers.

Zierau , Sachsen-anhalt , Germany , Kiel-financial-need , Household-management , Schleswig-holstein-state-capital-keel , Lord-mayor-fighter , Treasurer-zierau-thursday , Board-meeting , Kiel-budget , Under-finance-kiel

Boyens Medien: Corona lässt Kieler Finanznot wachsen

Boyens Medien: Corona lässt Kieler Finanznot wachsen
boyens-medien.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from boyens-medien.de Daily Mail and Mail on Sunday newspapers.

Zierau , Sachsen-anhalt , Germany , Kiel-financial-need , Household-management , Schleswig-holstein-state-capital-keel , Lord-mayor-fighter , Treasurer-zierau-thursday , Board-meeting , Kiel-budget , Under-finance-kiel

Corona-News-Ticker: Impfquote von Jugendlichen in SH am höchsten

Corona-News-Ticker: Impfquote von Jugendlichen in SH am höchsten
ndr.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ndr.de Daily Mail and Mail on Sunday newspapers.

Germany , Montenegro , Schleswig , Schleswig-holstein , Zierau , Sachsen-anhalt , Bremerhaven , Bremen , Switzerland , Saxony , Sachsen , Lower-saxony

Haushaltsentwurf 2022 der Stadt Kiel: Die Defizite drücken

Haushaltsentwurf 2022 der Stadt Kiel: Die Defizite drücken
kn-online.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from kn-online.de Daily Mail and Mail on Sunday newspapers.

Zierau , Sachsen-anhalt , Germany , Kiel-castle , Feedback-of-service-staff , Coalition-negotiations , City-council , Service-staff , S-administration , Design-of-administration , Office-space , Ora-convention-center

Kiel: Nachtragshaushalt genehmigt trotz Minus von 75 Millionen Euro

Kiel: Nachtragshaushalt genehmigt trotz Minus von 75 Millionen Euro
kn-online.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from kn-online.de Daily Mail and Mail on Sunday newspapers.

Zierau , Sachsen-anhalt , Germany , Fitness-program , Discussions-in-parliament , Kiel-budget , Treasurer-zierau , Board-meeting , Board-members , Core-set , Finance-committee

"Die Unschuldsvermutung" mit Ulrich Tukur in der ARD-Mediathek

"Die Unschuldsvermutung" mit Ulrich Tukur in der ARD-Mediathek
rp-online.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from rp-online.de Daily Mail and Mail on Sunday newspapers.

Austria , Salzburg , Zierau , Sachsen-anhalt , Germany , Austrian , Ulrich-tukur , Media-library , Ard-media-library , Falling-the , Innocence-presumption , First-new

Ulrich Tukur spielt Maestro-Macho: Vorhang zu, alle Fragen offen - Medien - Gesellschaft

Ulrich Tukur spielt Maestro-Macho: Vorhang zu, alle Fragen offen - Medien - Gesellschaft
tagesspiegel.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tagesspiegel.de Daily Mail and Mail on Sunday newspapers.

Zierau , Sachsen-anhalt , Germany , Ulrich-tukur , Easter-mayer , Television-viewers-it , Media-society , Storm-ingers , Most-important , Her-task , Her-cell-phone , Android-device

Ein taktloser Maestro - „Die Unschuldsvermutung"

Ein taktloser Maestro - „Die Unschuldsvermutung"
schwaebische.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from schwaebische.de Daily Mail and Mail on Sunday newspapers.

Stadl , Bayern , Germany , Zierau , Sachsen-anhalt , Ulrich-tukur , Easter-mayer , Makes-abuse , Danger-run , Stadl-above , Reporter-franciscan-finch