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Worldwide network develops SARS-CoV-2 protocols for research laboratories


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IMAGE: Scientists Martin Hengesbach (left) und Andreas Schlundt at the nuclear magnetic resonance (NMR) spectrometre at Goethe-University Frankfurt, Germany.
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Credit: Uwe Dettmar for Goethe-University Frankfurt, Germany
FRANKFURT. When the SARS-CoV-2 virus mutates, this initially only means that there is a change in its genetic blueprint. The mutation may lead, for example, to an amino acid being exchanged at a particular site in a viral protein. In order to quickly assess the effect of this change, a three-dimensional image of the viral protein is extremely helpful. This is because it shows whether the switch in amino acid has consequences for the function of the protein - or for the interaction with a potential drug or antibody. ....

Rio Preto , Santa Catarina , Switzerland General , United States , Frankfurt Am Main , Duque De Caxias , Estado Do Rio , Sesto Fiorentino , Baden Wüberg , Rio De Janeiro , Andreas Schlundt , Halle Saale , Martin Hengesbach , Harald Schwalbe , Charles Tanford Protein Centre , Lyon University , Chemical Biology At Goethe University , Institute Of Organic Chemistry , University Of Rio De Janeiro , Goethe Coronavirus Fund , Institute For Molecular Virology , University Of Florence , Oswaldo Cruz Foundation , Spanish National Research Council , Institute For Biochemistry , Institute Of Medical Biochemistry ,

New Data sheds light on genesis of our body's powerhouses


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IMAGE: The mitoribosome is attached to its membrane adaptor as it synthesises a bioenergetic protein (glow yellow).
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Credit: Dan W. Nowakowski and Alexey Amunts
Scientists uncover for the first time how the body s energy makers are made using Cryo-Electron Microscopy (cryo-EM) at eBIC within Diamond which is based in Oxfordshire.
A new paper published in
Science today (19 February 2021) by an international team of researchers reports an insight into the molecular mechanism of membrane-tethered protein synthesis in mitochondria. This is a fundamental new understanding of how the human mitoribosome functions and could explain how it is affected by mutations and deregulation that lead to disorders such as deafness and diseases including cancer development. ....

United States , United Kingdom , Eteläuomen Läi , Newcastle Upon Tyne , Karolinska Institutet , Uwe Richter , Alexey Amunts , Austin Choi , Brendanj Battersby , Priyanka Maiti , Yuriy Chaban , Yuzuru Itoh , Juni Andr , Rosalind Franklin Institute , National Institute Of Diabetes , Department Of Neurology , Science For Life Laboratory , Stockholm University , Department Of Biochemistry , Technology Facilities Council , Newcastle University , Department Of Medical Biochemistry , Research Council , Electron Physical Science Imaging Centre , University Of Helsinki , National Institutes Of Health ,

IRP's Robert Tycko Elected to National Academy of Sciences | NIH Intramural Research Program


NIH Researcher Recognized for Contributions to Structural Biology Techniques
Tuesday, January 19, 2021
IRP researcher Robert Tycko was elected to the National Academy of Sciences in 2020 for his important contributions to the field of structural biology.
The National Academy of Sciences (NAS), established in 1863, is comprised of the United States’ most distinguished scientific scholars, including nearly 500 Nobel Prize winners. Members of the NAS are elected by their peers and entrusted with the responsibility of providing independent, objective advice on national matters related to science and technology in an effort to advance innovations in the United States.
IRP senior investigator Robert Tycko, Ph.D., was one of two NIH researchers elected to the NAS in 2020, an honor he hopes will give him the opportunity to help other scientists and improve the way science is done. ....

United States , Reed Wickner , Richard Youle , Robert Tycko , National Academy Of Sciences , University Of California , National Institute Of Diabetes , University Of Pennsylvania , Intramural Research Program , Laboratory Of Chemical Physics , Structural Biology , National Academy , United State , Chemical Physics , National Institute , Kidney Diseases , Bell Laboratories , Research Program , ஒன்றுபட்டது மாநிலங்களில் , ரிச்சர்ட் நீங்கள் , தேசிய கலைக்கழகம் ஆஃப் அறிவியல் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , தேசிய நிறுவனம் ஆஃப் நீரிழிவு நோய் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , அகச்சிதைவு ஆராய்ச்சி ப்ரோக்ர்யாம் , ஆய்வகம் ஆஃப் இரசாயன இயற்பியல் ,